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EC number: 201-052-9
CAS number: 77-73-6
18% and 14% decrease in terminal body weight was observed for the high
dose males and females, respectively, as compared with their initial
body weights. The terminal body weight loss for the high dose groups, as
compared with the controls, was 18% for males and 13% for females. Both
observed body weight reductions are considered test substance-related
signs of systemic toxicity. The body weight loss in males is also
considered biologically significant.
statistically significant or biologically relevant effects on
micronuclei frequencies were observed in the bone marrow cells in any
dose group treated with DCPD/Codimer Concentrate. Although not
statistically significant, a depression of approximately 30% in the
PCE/NCE ratio was seen at 1750 mg/kg in females and demonstrates
exposure of target cells to the test substance.
vehicle and positive control groups exhibited a response consistent with
the laboratory’s historical control data. The positive control,
cyclophosphamide, induced a significant increase in the frequency of
micronucleated PCEs (p < 0.05).
Concentrate was evaluated for its ability to induce micronuclei in bone
marrow polychromatic erythrocytes (PCEs) in male and female mice using
groups of 5-7 mice/sex. Animals received 2 doses at 24 hour intervals
and were assessed 24 hours after the second dose.
not induce a statistically significant increase in micronucleated
polychromatic erythrocytes in male or female mouse bone marrow. The
highest dose administered on the study (1750 mg/kg body weight) gave
clear evidence of clinical signs (both sexes) and exposure of the bone
marrow to the substance (decreased PCE/NCE ratio) in females.
Based on these findings, DCPD/Codimer
Concentrate (CAS 68478-10-4) was considered negative in this in vivo
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