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EC number: 201-052-9
CAS number: 77-73-6
of mortality following single 6-hour inhalation exposure
Target Concentration (ppm)
Males: One died during exposure. 3 died immediately post-exposure. 2 found dead on the day after exposure.
Females: All found dead on the day after exposure.
Males: 2 found dead the day after exposure.
In this study, groups of 6 male and 6 female
Fischer 344 rats were exposed (whole body) to 46, 130, 260 or 557 ppm
dicyclopentadiene vapour for 6 hours and then observed daily for up to
14 days. At 557 ppm, one male died during exposure, 3 died immediately
post-exposure and 2 were found dead on the day after exposure; all
females were found dead on the day after exposure. At 260 ppm, two males
were found dead on the day after exposure, all females survived.
Clinical signs included loss of righting reflex, impaired gait,
stereotypic behaviour, laboured breathing, nasal discharge and
convulsions. The LC50 was 284 ppm (male) and 353 ppm (female),
equivalent to 1536 and 1910 mg/m3, respectively.
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