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EC number: 201-052-9 | CAS number: 77-73-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 November 1988 - 16 November 1099
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- n/a
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 77-73-6
- Molecular formula:
- C10H12
- Test material form:
- liquid
- Details on test material:
- - Supplier: Dow Chemical Europe SA
- Batch number (Sponsor's identification): DCPD 75%
- Name of test material (as cited in study report): DCPD 75%
- Physical state: clear, yellow-coloured liquid
- Composition of test material, percentage of components: 71.1% endo dicyclopentadiene, 0.8% exo dicyclopentadiene, 1.4% m-bicyclozonadiene, 15.2% CPD-MCPD codimers, 0.3% tricyclopentadiene, 1.3% CPD-butadiene codimer, 0.3% CPD-piperylene codimer, 0.3% CPD-isoprene codimer, <0.1% benzene , remainder misc. hydrocarbons.
- Specific gravity: 0.971
- Storage condition of test material: room temperature
Constituent 1
- Specific details on test material used for the study:
- - Supplier: Dow Chemical Europe SA
- Batch number (Sponsor's identification): DCPD 75%
- Name of test material (as cited in study report): DCPD 75%
- Physical state: clear, yellow-coloured liquid
- Composition of test material, percentage of components: 71.1% endo dicyclopentadiene, 0.8% exo dicyclopentadiene, 1.4% m-bicyclozonadiene, 15.2% CPD-MCPD codimers, 0.3% tricyclopentadiene, 1.3% CPD-butadiene codimer, 0.3% CPD-piperylene codimer, 0.3% CPD-isoprene codimer, <0.1% benzene , remainder misc. hydrocarbons.
- Specific gravity: 0.971
- Storage condition of test material: room temperature
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd., Moston, Sandbach, Cheshire, UK
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.22-2.54kg
- Housing: Individually in suspended metal cages
- Diet: Rabbit Diet ad libitum (Preston Farmers Ltd., New Leake, Boston, Lincolnshire, UK)
- Water: Mains water ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 16-22°C
- Humidity: 54-67%
- Air changes (per hr): Approximately 15/hour
- Photoperiod: 12 hrs dark / 12 hrs light):
IN-LIFE DATES: From: 9 November 1988 To: 16 November 1988
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- % coverage: not specified
- Type of wrap if used: gauze patch held in place with surgical adhesive tape under a Tubigrip corset
REMOVAL OF TEST SUBSTANCE
- Washing (if done): swabbed with water
- Time after start of exposure: 4 hr after application
SCORING SYSTEM: Draize scale
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days.
- Remarks on result:
- other: possible hyperkeratinisation at 7 days in all 3 animals.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- n/a
- Other effects:
- n/a
Any other information on results incl. tables
Skin irritation scores according to the Draize scheme
Time |
Erythema (Test/Control sites) |
Oedema (Test/Control sites) |
||||
Animal number |
34F |
43F |
80M |
34F |
43F |
80M |
after 1 hour |
1 |
2 |
1 |
1 |
2 |
1 |
after 24 hours |
2 |
2 |
2 |
4 |
4 |
3 |
after 48 hours |
2 |
2 |
2 |
2 |
2 |
1 |
after 72 hours |
2 |
2 |
2 |
2 |
2 |
1 |
mean scores 24-72h |
2 |
2 |
2 |
2.6 |
2.6 |
1.7 |
Overall mean score (24-72 h) |
2 |
2.3 |
Well-defined erythema persisted at all treated skin sites at 24, 48 and 72 hour observations. Signs of possible hyperkeratinisation were noted on day 7. No oedema was noted on day 7. No other adverse dermal reactions were noted during the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- In a skin irritation study with dicyclopentadiene 75% in rabbits, overall mean scores (24, 48 & 72 hr) were 2 for erythema and 2.3 for oedema. Dicyclopentadiene 75% was therefore considered to be a moderate irritant to rabbit skin.
- Executive summary:
Skin irritation was assessed in a group of 3 New Zealand white rabbits. 0.5 mL of dicyclopentadiene 75% was applied to an area of clipped, intact skin under a semi-occlusive dressing for 4 hours. Animals were observed at 1 and 4 hours after removal of the patch and then daily for 7 days. Well-defined erythema and slight to severe oedema was present at skin sites of all rabbits at 24, 48 and 72 hour observations. On day 7 no oedema was noted but there were signs of possible hyperkeratinisation. No other adverse dermal reactions were noted during the study. The overall mean scores (24, 48 & 72 hr) were 2 for erythema and 2.3 for oedema, and the mean oedema score exceeded 2.3 for two of the three animals. DCPD 75% was a therefore considered a moderate irritant to rabbit skin, therefore, classification as H315 "causes skin irritation", according to CLP, is required.
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