Registration Dossier

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: results of a literature review, published in peer reviewed literature, acceptable with restrictions

Data source

Reference
Reference Type:
publication
Title:
Odor as an aid to chemical safety: odor thresholds compared with threshold limit values and volatiles for 214 industrial chemicals in air and water dilution
Author:
Amoore JE & Hautala E
Year:
1983
Bibliographic source:
J. Appl. Toxicol. 1983 Vol 3 272-290

Materials and methods

Type of study / information:
Literature review of odour thresholds
Endpoint addressed:
respiratory irritation
Principles of method if other than guideline:
The literature has been reviewed to provide quantitative data on the odour thresholds of 214 chemicals. Data on the volatility, solubility, ionisation and water-air distribution ratio at 25ºC are included. A safe dilution factor and an odour safety factor are calculated.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reference substance 001
Cas Number:
77-73-6
Molecular formula:
C10H12
Constituent 2
Reference substance name:
Dicyclopentadiene
IUPAC Name:
Dicyclopentadiene

Method

Ethical approval:
not specified
Details on study design:
no data

Results and discussion

Results:
Air odour threshold dicyclopentadiene: 0.0057±1.9 ppm. Safe dilution factor: 720. Odour safety factor (based on TLV of 5 ppm): 870. More than 90% of distracted persons perceive warning of TLV concentration in the air.

Any other information on results incl. tables

Air-dilution odour thresholds. Threshold limit value: 5 ppm v/v. Volatility at 25ºC: 3600 ppm v/v.

Applicant's summary and conclusion

Conclusions:
Threshold limit value: 5 ppm v/v; Volatility at 25ºC: 3600 ppm v/v; Air odour threshold: 0.0057±1.9 ppm; Safe dilution factor: 720; Odour safety factor: 870; Odour safety class: A (more than 90% of distracted persons perceive warning of TLV concentration in the air)
Executive summary:

A literature search on olfactory and physiochemical properties of volatile substances listed in the Threshold Limit Values (1982) was conducted. The authors compiled, averaged, re-calculated or extrapolated from published information. The values and odour safety class identified for dicyclopentadiene were: Threshold limit value: 5 ppm v/v; Volatility at 25ºC: 3600 ppm v/v; Air odour threshold: 0.0057±1.9 ppm; Safe dilution factor: 720; Odour safety factor: 870; Odour safety class: A (more than 90% of distracted persons perceive warning of TLV concentration in the air).

Categories Display