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EC number: 201-052-9
CAS number: 77-73-6
Table: Concentrations tested and
corresponding observed percentage mortalities for channel catfish (Ictalurus
punctatus) exposed to dicyclopentadiene ( DCPD) for 24 , 48 and 96
This is a 96 h LC50 experimental
study, non-GLP and similar to standard guidelines, with notable
restrictions in design and/or reporting but contributing to weight of
evidence assessment. The 96 h LC50 Ictalurus punctatus
was reported to be 15.7 mg/L
The 96 hour LC50 is 15.7 mg/L.
The estimated LC50 value from TLM QSAR is 6.712 mg/L.
The experimental value was used for the
chemical safety assessment.
An Environmental Agency Japan test following
OECD guideline 203, using semi-static conditions without analytical
confirmation of exposure concentrations showed the 96-hour LC50
to be 4.3 mg/L. This study was unavailable for review but was included
in the OECD SIDS for DCPD.
Bentley et al (1976) tested the toxicity of
dicyclopentadiene to four species of fish. The range of LC50 values
reported within the paper was between 15.7 -31.1 mg/L. The study
followed a method similar to standard guidelines but did not include
analytical confirmation of the exposure concentrations.
A QSAR result has also been included as part
of the weight of evidence, which used the ECOSAR program to derive a
96-hour LC50 of 9.8 mg/L and Target Lipid modelling to derive
an estimated LL50 for this substance is 6.712 mg/L.
The lowest of the measured results which are
considered to be reliable has been conservatively selected as the key
value for this endpoint.
The 96-hour LC50 for freshwater
fish is 15.7 mg/L (Bentley et al 1976).
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