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EC number: 201-052-9
CAS number: 77-73-6
of 5 male and 5 female Sprague Dawley rats (fasted overnight) were dosed
by gavage at levels of 500, 794, 1260 or 2000 mg/kg dicycolpentadiene
and were observed daily for 14 days after dosing. At
the 4 hour observation period rats
dosed with high levels of dicyclopentadiene (1260 or 2000 mg/kg bw) had
hunched posture, piloerection, lethargy and decreased respiratory rate,
with ptosis and occasional signs of ataxia seen in those dosed at 2000
mg/kg bw. All
rats dosed at 1260 or 2000 mg/kg bw died one or two days after dosing. Haemorrhagic
lungs, dark liver and sloughing of the non-glandular gastric epithelium
was seen in decedents. The LD50 was calculated to be 590 mg/kg bw
(male/female), 512 mg/kg (male) and 676 mg/kg/bw (female).
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