3a,4,7,7a-tetrahydro-4,7-methanoindene

Toxicity to terrestrial arthropods

Link to relevant study record(s)

Reference

Endpoint:

toxicity to terrestrial arthropods: long-term

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

up to 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

See attached justification

Qualifier:

no guideline required

Principles of method if other than guideline:

TThe endpoint calculated is the LL50, EL50, and NOELR -
The narcosis target lipid model was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.

GLP compliance:

no

Remarks:

QSAR

Application method:

other: QSAR

Specific details on test material used for the study:

A logkow of 2.78 was used as input for the prediction

Analytical monitoring:

not required

Remarks:

QSAR

Details on sampling:

N/A

Vehicle:

no

Remarks:

QSAR

Details on preparation and application of test substrate:

N/A

Test organisms (species):

Folsomia candida

Animal group:

Collembola (soil-dwelling springtail)

Details on test organisms:

N/A

Study type:

other: QSAR

Limit test:

no

Post exposure observation period:

N/A

Test temperature:

N/A

pH (if soil or dung study):

N/A

Humidity:

N/A

Photoperiod and lighting:

N/A

Details on test conditions:

N/A

Nominal and measured concentrations:

N/A

Reference substance (positive control):

no

Remarks:

QSAR

Toxic reference:

N/A

Key result

Duration:

28 d

Dose descriptor:

other: LL50

Effect conc.:

55.475 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

Result from QSAR

Key result

Duration:

28 d

Dose descriptor:

other: NOELR

Effect conc.:

10.627 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks on result:

other:

Remarks:

Result from QSAR

Details on results:

N/A

Results with reference substance (positive control):

N/A

Reported statistics and error estimates:

N/A

N/A

Validity criteria fulfilled:

not applicable

Remarks:

QSAR

Conclusions:

The calculated LL50 is 55.475 mg/kg soil dw and NOELR is 10.627 mg/kg soild dw.

Executive summary:

The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted 28-day effect values for the substance were 55.475 and 10.627 mg/kg soil dw for short-term (LL₅₀) and long-term effects (NOELR), respectively.

The prediction is considered to fall within the model domain

Description of key information

TLM QSAR modelling was used to estimate the LC₅₀ and EC₁₀ values towards F. candida. The calculated LL₅₀ is 55.475 mg/kg soil dw and NOELR is 10.627 mg/kg soil dw.

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil dwelling arthropods:

55.475 mg/kg soil dw

Long-term EC10, LC10 or NOEC for soil dwelling arthropods:

10.627 mg/kg soil dw