Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-052-9 | CAS number: 77-73-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- up to 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached justification
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The endpoint calculated is the LL50, EL50, and NOELR -
The narcosis target lipid model was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points. - GLP compliance:
- no
- Remarks:
- QSAR
- Specific details on test material used for the study:
- A logkow of 2.78 was used as input for the prediction
- Analytical monitoring:
- not required
- Remarks:
- QSAR
- Details on sampling:
- N/A
- Vehicle:
- no
- Remarks:
- QSAR
- Details on sediment and application:
- N/A
- Test organisms (species):
- Lumbriculus variegatus
- Details on test organisms:
- N/A
- Study type:
- other: QSAR
- Test type:
- other: QSAR
- Water media type:
- other: QSAR
- Type of sediment:
- not specified
- Remarks:
- QSAR
- Limit test:
- no
- Post exposure observation period:
- N/A
- Hardness:
- N/A
- Test temperature:
- N/A
- pH:
- N/A
- Dissolved oxygen:
- N/A
- Salinity:
- N/A
- Ammonia:
- N/A
- Conductivity:
- N/A
- Nominal and measured concentrations:
- N/A
- Details on test conditions:
- N/A
- Reference substance (positive control):
- no
- Remarks:
- QSAR
- Key result
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 100.47 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Result from QSAR
- Key result
- Duration:
- 28 d
- Dose descriptor:
- other: NOELR
- Effect conc.:
- 19.247 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- biomass
- Remarks on result:
- other:
- Remarks:
- Result from QSAR
- Details on results:
- N/A
- Results with reference substance (positive control):
- N/A
- Reported statistics and error estimates:
- N/A
- Validity criteria fulfilled:
- not applicable
- Remarks:
- QSAR
- Conclusions:
- The estimated LL50 for this substance is 100.470 mg/kg sediment dw and the NOELR was 19.247 mg/kg sediment dw.
- Executive summary:
The registered substance is highly volatile which complicates environmental testing. Therefore, a modeling framework is needed to account for the bioavailability of the substance to perform read-across and data gap filling. The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted effect values (28-days) for this substance were 100.470 and 19.247 mg/kg sediment dw for short-term (LL50) and long-term effects (NOELR), respectively.
The prediction is considered to fall within the model domain.
Reference
N/A
Description of key information
TLM QSAR modelling was used to estimate the LC50 and EC10 values towards L. variegatus. The calculated LL50 is 100.47 mg/kg sediment dw and NOELR is 19.247 mg/kg sediment dw.
Key value for chemical safety assessment
- EC50 or LC50 for freshwater sediment:
- 100.47 mg/kg sediment dw
- EC10, LC10 or NOEC for freshwater sediment:
- 19.247 mg/kg sediment dw
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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