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EC number: 201-052-9
CAS number: 77-73-6
75%: Eye irritation scores according to the Draize scheme
after 1 hour
after 24 hours
after 48 hours
after 72 hours
mean scores 24-72h
= dulling of corneal surface
Eye irritation was assessed in 3 New Zealand
white rabbits. 0.1 mL dicyclopentadiene 75% was instilled into the
conjunctival sac and the eyes were scored for irritation responses at 1,
24, 48 and 72 hours and at 7 days after instillation. At 1 hour, corneal
dulling was present in 2 eyes, iridial inflammation and moderate
conjunctival irritation were present in all 3 eyes, giving an overall
mean score of 18.5 at 1 hour, which corresponds to moderate irritation
(Kay and Callandra, 1962). Signs of irritation regressed to minimal in 2
eyes at 24 hours but persisted in 1 animal at 48 and 72 hours. All
effects were fully reversible within 7 days. Dicyclopentadiene 75% was a
moderate irritant to the rabbit eye at 1 hour but was practically
non-irritating at 24, 48 and 72 hours. According to GHS / CLP labelling
regulations dicyclopentadiene is a non-irritant and requires no symbol
or risk phrase.
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