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EC number: 202-853-6
CAS number: 100-44-7
The authors tested the teratogenicity of benzyl chloride (CAS n° 100 -44
-7) by exposing female Sprague-Dawley rats at doses of 0 (vehicle: corn
oil), 50, 100 mg/kg/day from day 6 through day 15 of gestation. The
postion and number of implantations, resorptions, and live fetuses and
the mean fetal weight were recorded. External and visceral abnormalities
and skeletal defects were also checked in the sampled fetuses.
No signs of toxicity was observed in the dams. The number of
implantations, resorptions, and live fetuses and the mean fetal weight
were not affected at both dosage groups. The only significant change was
the reduction of fetal length at 100 mg/kg. All live fetuses were normal
in the external appearance. No major skeletal or visceral abnormalities
resulting from treatment with benzyl chloride were noted. No significant
increase was detected in the number of skeletal and visceral variations.
In the test conditions, based on the reduction of fetal length, a NOEL
for fetal toxicity was considered to be 50 mg/kg/day and a NOEL for
teratogenicity was considered to be 100 mg/kg/day because no teratogenic
changes were observed.
The GLP status of the study is not known but is well described. Besides,
the study is based on generally well accepted scientific principles.
Therefore , this study should be considered as reliable with
restrictions, a Klimisch 2.e study.
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