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EC number: 202-853-6
CAS number: 100-44-7
The authors tested the mutagenicity of
benzyl chloride in vivo according to a methodology similar to the OECD
guideline 474 (Mammalian Erythrocyte Micronucleus Test) on Swiss-Webster
male and female mice. Eight mice per dose were injected
intraperitoneally less than 8 mL/kg bw of benzyl chloride solutions
freshly diluted in DMSO twice. The concentrations corresponded to 1/8
LD50, 1/4 LD50 and 1/2 LD50 previously established in a screening test.
The injections of benzyl chloride solutions took place 30 and 6 hours
prior the preparation of the bone marrow. At the end of the exposure
period, mice were sacrificed and bone marrow fluids were collected,
stained and the number of micronucleated polychromatic erythrocytes on
per thousand were counted to establish cytogenetic damages. Results for
the benzyl chloride were then compared with other tested substances.
In the test conditions, the authors
established that benzyl chloride induced significantly micronucleated
polychromatic erythrocytes compared with solvent control. However, this
increase was not estimated dose dependant and the induction rate was
lower than the 3-fold threshold generally recommended. Benzyl chloride
should therefore be considered as a potential mutagen but would require
further testing to establish its mutagenicity on somatic cells. Finally,
these results should be interpretated as ambiguous.
The GLP status of this study is unknown.
However, it was sufficiently described and very similar to the OECD
guideline 474. Only a minor deviation was noted on the characterisation
of the erythrocyte population (immature erythocytes number not
reported). Therefore, this study should be considered as comparable to a
guideline study with acceptable restrictions, a Klimisch 2.c study.
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