α-chlorotoluene

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The authors tested the toxicity of benzylchloride for two fish species according to the OECD guideline 203 as published in 1981. No GLP standards are specified and very few details are given concerning the materials and methods. As such this study should be considered as reliable with restrictions, a Klimisch 2.a study, a guideline sitdy without detailled documentation.

Data source

Reference

Reference Type:

publication

Title:

Vergleich der Empfindlichkeit von Brachydanio rerio and Leuciscus idus bei der Untersuchung der Fischtoxizität von chemischen Verbindungen und Abwässern

Author:

Wellens H.

Year:

1982

Bibliographic source:

Z. Wasser Abwasser Forsch. 15(2): S.49-52

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

α-chlorotoluene

EC Number:

202-853-6

EC Name:

α-chlorotoluene

Cas Number:

100-44-7

Molecular formula:

C7H7Cl

IUPAC Name:

(chloromethyl)benzene

Constituent 2

Reference substance name:

chloromethylbenzene

IUPAC Name:

chloromethylbenzene

Details on test material:

- Name of test material (as cited in study report): benzylchlorid

No more data available

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

other: Brachydanio rerio and Leuciscus idus

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Remarks on exposure duration:

96h for Brachydanio rerio and 48h for Leuciscus idus

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

2.8 mg/L

Basis for effect:

mortality (fish)

Remarks on result:

other: Brachydanio rerio

Effect concentrations 2

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

4 mg/L

Basis for effect:

mortality (fish)

Remarks on result:

other: Brachydanio rerio

Effect concentrations 3

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

5.7 mg/L

Basis for effect:

mortality (fish)

Remarks on result:

other: Brachydanio rerio

Effect concentrations 4

Duration:

48 h

Dose descriptor:

LC0

Effect conc.:

11.3 mg/L

Basis for effect:

mortality (fish)

Remarks on result:

other: Leuciscus idus

Effect concentrations 5

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

16 mg/L

Basis for effect:

mortality (fish)

Remarks on result:

other: Leuciscus idus

Effect concentrations 6

Duration:

48 h

Dose descriptor:

LC100

Effect conc.:

22.6 mg/L

Basis for effect:

mortality (fish)

Remarks on result:

other: Leuciscus idus

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Conclusions:

The authors tested the toxicity of benzyl chloride to two fish species (i.e. Brachydanio rerio and Leuciscus idus) according to the OECD guideline 203 as published in 1981. Under the test conditions, the LC50 after 96h for Brachydanio rerio was estimated at 4 mg/L and LC50 after 48h for Leuciscus idus was at 16 mg/L. Considering the LC50-value for Brachydanio rerio, benzylchloride should not be classified as hazardous to the aquatic environment according to the CLP regulation EC n° 1272-2008. Classification of benzylchloride based on the LC50-value of Leuciscus idus is not possible, since the CLP regulation EC n° 1272-2008 requires the LC50 after 96h.

Executive summary:

The authors tested the toxicity of benzyl chloride (CAS n° 100-44-7) to two fish species (i.e. Brachydanio rerio and Leuciscus idus) according to the OECD guideline 203 as published in 1981. The duration of this static test was 96h for Brachydanio rerio and 48h for Leuciscus idus. No further data are reported on the test conditions.

Under the test conditions, the LC50 -values for Brachydanio rerio and Leuciscus idus were estimated at 4 mg/L and 16 mg/L respectively. Hence the LC50-value after 96h for Brachydanio rerio indicates that benzylchloride should not be classified as hazardous to the aquatic environment according to the CLP regulation EC n° 1272-2008. Classification of benzylchloride based on the LC50-value of Leuciscus idus however is not possible, since the CLP regulation EC n° 1272-2008 requires the LC50 after 96h.

No GLP standards are specified and very few details are given concerning the materials and methods. However, since this study was conducted according to the OECD guideline 203, this study should be considered as reliable with restrictions, a Klimisch 2.a, a guideline study without detailled documentation.