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EC number: 202-853-6
CAS number: 100-44-7
Table 1: Scores for cornea,
iris and conjunctivae after 1h, 24h, 48h, 72h, 120h and 168h for each
test organism. For all time point also the mean total
score is given.
No further data available
The authors tested the acute eye irritation
of New Zealand Albino rabbits exposed to benzyl chloride (CAS n°
100-44-7) following a methodology similar to the OECD guideline 405
(Acute eye irritation/corrosion). Six rabbits were exposed for 24h to
0.1 mL undiluted benzyl chloride and the effects
on the cornea, iris and conjunctivae were recorded at 1, 24, 48, 72,
120, 168 hours and 10 days, and graded according to FHSA scoring
Immediately after the
exposure, the rabbits exhibited discomfort. The reaction to the test
substance increased and the maximum mean total score (i.e. 23.8/110.0)
was reached after 24h. At this time point the test specimens displayed
areas of barely perceptible corneal dullness, severe erythema, slight to
moderate edema and copious discharge. From 48 to 168 there was a gradual
improvement and after 10 days all scored zero.
Thus results indicate that benzyl chloride
should be considered as a mild irritant according to FHSA criteria.
However, benzyl chloride cannot be classified according to the CLP
regulation (EC) N° 1272/2008 since the criteria for scoring eye damages
While GLP standards are not specified,
materials and methods as well as results are sufficiently described. As
the study was performed with a methodology similar to the OECD guideline
405 and as no deviations are observed, this study should be considered
as reliable with restrictions, a Klimisch 2.c, comparable to a guideline
study with acceptable restrictions.
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