Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-853-6
CAS number: 100-44-7
_ Table 1: Dosages, average
initial weight, amount of rats dosed, mortality and time of mortality.
No further data available
The authors tested the acute oral toxicity
of benzyl chloride (CAS n° 100-44-7) with a methodology similar to the
OECD Guideline 401 (Acute Oral Toxicity). A total of five Sprague-Dawley
albino rats (2 or 3 of each sex) were exposed to four dosages of
undiluted test substance and mortality, signs of intoxication and gross
pathalogy were checked.
Under these test conditions, an LD50 was
found of 560 mg/kg (95% C.L.: 510 -620 mg/kg). Hence, the result
indicates that benzyl chloride should be classified harmfull if
swallowed according to the CLP regulation (EC) No 1272/2008.
GLP standards were not specified but
sufficient data was given concerning materials and methods. The method for
the calculation of the LD 50 is unknown and the number of animals per sex
is not consistent for all concentrations. A greater number of animals would
have been beneficial but basic checkings and results are reported. Hence
the study should be considered reliable with restrictions, a Klimisch 2.e
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again