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EC number: 202-853-6
CAS number: 100-44-7
Dose of 30 mg/kg (12.9 mg/kg bw/day)
- a few females had hyperkeratosis of the
Dose of 62 mg/kg (26.6 mg/kg bw/day)
- females: only 4 survived to 26 weeks;
acute myocardial necrosis in 4 and hyperplasia of the forestomachwas
- statistically significant depression of
weight gain in males, in females the weight gain depression was smaller
Dose of 125 mg/kg (53.6 mg/kg bw/day)
- all females died within 2 weeks
- all males died within 3 weeks
- cause of death was mainly severe acute and
chronic gastritis of the forestomach (often with ulcers). In many cases
there was also acute myocardial necrosis and edema of the heart
Dose of 250 mg/kg (107.1 mg/kg bw/day)
- all rats died within 2 weeks
- common cause of death was acute myocardial
necrosis and edema of the heart
The authors tested the oral toxicity of
benzyl chloride (CAS n° 100-44-7) by repeatedly exposing female and male
F344 rats to the test substance by oral gavage in a subchronic test. The
test substance was mixed with corn oil and administered once a day,
three times a week for 26 weeks.Ten rats/sex were exposed to 15, 30, 62,
125 or 250 mg/kg and a control group was included. During the experiment
the rats were weighed and at the end of the experiment tha animals were
sacrificed and examined histopathologically.
In these test conditions, a few females
exposed to 30 mg/kg (12.9 mg/kg bw/day) had hyperkeratosis of the
forestomach. At a dose of 62 mg/kg (26.6 mg/kg bw/day) only four females
survived till the end of the experiment (26 weeks). Furthermore acute
myocardial necrosis was observed in 4 female rats and hyperplasia of the
forestomach was also noted. Also at 62 mg/kg depression of weight gain
was seen in females and males, but only for males this decrease in
weight gain was statistically significant. Exposure to 125 mg/kg (53.6
mg/kg bw/day) led to death within 2 weeks for all females and 3 weeks
for all males. The cause of death was mainly severe acute and chronic
gastritis of the forestomach (often with ulcers) and in many cases there
was also acute myocardial necrosis and edema of the heart. Finally after
exposure to 250 mg/kg (107.1 mg/kg bw/day) all rats died within 2 weeks
and the most common cause of death was acute myocardial necrosis and
edema of the heart.
Finally, in the test conditions , the
aurhors established the NOEL was 6.4 and 12.9 mg/kg bw/day and the LOEL
was 12.9 and 26.6 mg/kg bw/day for female and male rats respectively.
No data is available on the GLP status of
the study. Although some details of the study are lacking, the study
itself is well conducted, well documented, meets generally accepted
scientific principles and acceptable for assessment. Therefore we
consider it reliable with restrictions, Klimisch 2e.
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