Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-853-6
CAS number: 100-44-7
rates were investigated among British workers exposed to benzotrichloride
(98077), benzal-chloride (98873), benzyl-chloride (100447),
and benzoyl-chloride (98884) at a factory that manufactured chlorinated
study population included 163 exposed and 790 unexposed
factory workers employed for at least 6 months between 1961 and 1970. Death
certificates were reviewed for the 91 subjects known to have died. Standardized
Mortality Ratios (SMRs) were calculated using the mortality
rates of the general population of England and Wales as comparison. A
second analysis was performed using the Regression Models in
Life Tables technique.
all causes and for causes other than cancer,
SMRs tended to increase with time since first employment. Elevated
SMRs were found among the exposed group for all causes, allcancers,
digestive system cancers, and respiratory system cancers. The unexposed
group had elevated SMRs for cancers of the buccal cavity and throat. For
both groups of workers combined, SMRs were increased for all causes
and all cancers.
In the survival analysis using the Cox
Proportional Hazards model, adjusting for age at entry to the survey and
the time period when employment began, a statistically significant
association between estimated cumulative exposure and deaths from cancer
at all sites (but neither digestive nor respiratory cancers
individually), was found for persons first employed before 1951.
authors conclude that exposed workers employed before 1951 have an increased
risk of cancer of the respiratory and digestive systems. Based
previous studies, they suggest that the most likely carcinogen is
As the authors mention it, cohort population
design may have been unappropriate and introduce some bias in the
experiment, furthermore the size of the cohorts has little statistical
meaning. Besides, characterization of the exposure may have also
introduce a bias as both categories (CT- and CT+) were subjective.
Finally, no real measurement on exposure to benzyl chloride is done and
no specific results on it are available. Altogether, these parameters
raise uncertainties on the conclusion of the impact of benzyl chloride
on workers. However, it gives little evidence and raises concerns on
benzyl chloride impacts on workers. The study is well documented and
based on generally accepted scientific principles.
Therefore, considering all these elements,
this study should be considered as valid with restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again