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Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study is insufficiently described as sampling and quantification are not known. Therefore, this study should be considered as not assignable due to insufficient documentation.

Data source

Reference
Reference Type:
publication
Title:
Occupational exposure to benzyl chloride and benzal chloride due to contaminated butyl benzyl phtalate
Author:
Rittfeld L.M.
Year:
1983
Bibliographic source:
Scand. J. Work Environ Health, 9, 367-368.

Materials and methods

Type of study / information:
Occupational exposure to benzyl chloride
Endpoint addressed:
not applicable
Principles of method if other than guideline:
Exposure levels to benzyl chloride have been assessed in industrial PVC flooring processors plants
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
α-chlorotoluene
EC Number:
202-853-6
EC Name:
α-chlorotoluene
Cas Number:
100-44-7
Molecular formula:
C7H7Cl
IUPAC Name:
(chloromethyl)benzene
Constituent 2
Reference substance name:
Chloromethylbenzene
IUPAC Name:
Chloromethylbenzene
Details on test material:
- Name of test material (as cited in study report): benzyl chloride
No further data

Method

Ethical approval:
not applicable
Details on study design:
Exposure levels of benzyl chloride were measured in air of manufacturing plant of PVC floorings near manufacturing lines.
Exposure assessment:
measured
Details on exposure:
No data

Results and discussion

Results:
0.03 mg/m³ near the manufacturing lines of PVC floorings was detected and 0.03 mg/m³ in air near surface film manufacturing lines was detected. Benzyl chloride was a contaminant of butyl benzyl phthalate used as a plasticizer in PVC floorings. Benzyl chloride was also detected in the atmosphere over a 10-day old vinyl floor tile.

Applicant's summary and conclusion

Conclusions:
In this study, the authors found that workers in a PVC floorings plant were exposed to 0.03 mg/m³ or 0.03 mg/m³ near processing machines of benzyl chloride as a contaminant of butyl benzyl phthalate.
Executive summary:

In this study, exposure levels of benzyl chloride were measured in air of manufacturing plant of PVC floorings near manufacturing lines after some cases of occupational irritation were noted.

0.03 mg/m³ of benzyl chloride near the manufacturing lines of PVC floorings was detected and 0.03 mg/m³ in air near surface film manufacturing lines was detected. Benzyl chloride was determined to be a contaminant of butyl benzyl phthalate used as a plasticizer in PVC floorings. Benzyl chloride was also detected in the atmosphere over a 10-day old vinyl floor tile.

However, there is no mention of the quantification method neither on the sampling method. Results are not sufficiently described and specific context of the occupational exposure is not clear. Therefore, this study should be considered as not assignable ude to insufficient documentation.

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