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EC number: 202-853-6
CAS number: 100-44-7
The authors tested the impact of benzyl
chloride (CAS n° 100 -44 -7) inhalation on the murine host defense
system.Female CD1 mice were exposed to saturated vapors of benzyl
chloride in individual cages for three hours or daily during three hours
for five days. Mice exposed were challenged by pathogens to assess the
viability of their immune system.
The first experiment consisted in an
infectious aerosol challenge experiment: The streptococus infectivity
model was used to determine the effect of the inhaled organic vapors on
succeptibility to respiratory infection. Mice exposed to the vapors were
simultaneously challenged with an aerosol of viable Streptococcus
zooepidemicus (group C). Ensuing deaths were recorded daily over a 14
-day observation period.
The second experiment consisted in a
pulmonary bactericidal activity test. 35S- Klebsiella pneumonia
(noncapsulated) disseminated with a Retec X-70 disposable nebulizer were
used for determination of the in vivo bactericidal activity of alveolar
macrophages. Bactericidal clearance was determined in the lungs of
individual animals from both treated and control mice that
simultaneously inhaled aerosols of the viable radiolabeled bacteria. The
ratio of the viable bacterial counts to the radioactive counts in each
animal's lungs provides an estimate of the rate at which bacteria are
destroyed 3 hr after infection.
In the test conditions, the authors did not
found a statistical difference between the treated mice and the controls
in the infectious aerosol challenge. However, in the pulmonary
bactericidal activity, the authors found a significant difference (p<0.01)
between the treated and the control mice when exposed to a single
exposure session. However, these results were not similar with the repeated
dose inhalation. These results prove that benzyl chloride may be
considered as a potent immuno-modulator and further testing would be required
to clarify the situation. Also, other test system should be tested.
This study is well documented and based on generally
accepted scientific principles.It then should be considered as reliable with
restrictions, a Klimisch 2.e study.
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