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EC number: 202-853-6
CAS number: 100-44-7
No mortality in treated and control groups
Histology of nasal passages:
Control: No histological disease, no
neutrophils and no other inflammatory exudate
Treated animals: respiratory and olfactory
epithelia lesion was observed at 46 ppm. Severity of lesions was severe
to very severe but no relation was observed to exposure duration.
Trachea and lungs:
The authors tested the repeated dose
inhalation toxicity of benzyl chloride (CAS n° 100 -44 -7) by
identifying and comparing the histological changes induced in the
respiratory tract of Swiss male mice. Three subacute repeated dose tests
with different exposure duration were performed and in each one animals
were exposed to the test substance 6 hours per day. The following
exposure durations were used: (1) four consecutive days of exposure, (2)
exposing animals five consecutive days in the first week and four
consecutive days in the second week and (3) exposing animals five
consecutive days in each of the first 2 weeks and four consecutive days
in the third week. For each of these exposure scenarios two
concentrations were tested (i.e. 22 and 46 ppm) and 10 mice were exposed
per dose. Per dose tested a control group of five mice was included.
Neither mortality nor injuries in the
trachea and lungs were observed in all treated as well as the control
mice. Furthermore no histological disease, no neutrophils and no other
inflammatory exudate was noted in the nasal passages of the control
mice. At the low dose exposure of 22 ppm no effects were observed caused
by the treatment, thus the NOEL is 22 ppm. The LOEL is 46 ppm and mice
exposed to this dosis exhibited respiratory and olfactory epithelia
lesions. Although these lesions were severe to very severe no relation
to the exposure duration was observed.
GLP status of the study is unknown, but it is sufficiently described,
based on generally well accepted scientific principles and acceptable
Therefore, this study should be considered reliable with restrictions,
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