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EC number: 202-853-6
CAS number: 100-44-7
The authors tested the sensory irritation
potential of benzyl chloride (CAS n° 100 -44 -7) by following the
decrease in the respiratory rate of six Swiss-OF1 mice (weighing 23 -27
g) exposed during five minutes (RD50) to vapours of the test substance.
Respiratory frequency was monitored by a plethysmograph.
The concentration that caused a 50 %
decrease in the respiratory rate from baseline was calculated using
least-squares regression analysis and gave a RD50 for benzyl chloride of 17
ppm. This RD50 reflects the sensory irritation potential according to
No clear conclusion of the authors was drawn
on the real sensory irritation potential of benzyl chloride. However,
this value may help for a weight of evidence for a classification as a
specific target organ toxicant (here respiratory tract) following single
exposure category 3.
This study is well described and is based on
recognized scientific principles. Therefore, this study should be
considered as reliable with restrictions and acceptable for assessment.
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