EU-MEDICAL_DEVICES-ANX_I_7_8

Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Directive 93/42/EEC, 12 July 1993, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances in accordance with the Medical Devices Directive's (MDD) design and construction requirements pursuant to Annex I, Part II (7) & (8) (i.e., chemical, physical and biological properties; and infection and microbial contamination). Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 93/42/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

Last updated 14 mai 2024. Database contains 4753 unique substances/entries.
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204-211-0
117-81-7
Repr. 1B
yes
203-924-4
111-96-6
Flam. Liq. 3; Repr. 1B
yes
204-212-6
117-82-8
Repr. 1B
yes
280-084-5
82985-35-1
Eye Dam. 1
200-237-1
55-55-0
Acute Tox. 4; STOT RE 2; Skin Sens. 1
205-137-1
134-31-6
Acute Tox. 4
208-832-8
542-88-1
Flam. Liq. 2; Carc. 1A; Acute Tox. 2; Acute Tox. 3; Acute Tox. 4
276-205-6
71957-07-8
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
233-118-8
10039-54-0
Met. Corr. 1; Carc. 2; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
239-703-4
15627-09-5
Flam. Sol. 1; Acute Tox. 4; STOT RE 2; Eye Dam. 1
214-604-9
1163-19-5
yes
202-328-1
94-37-1
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
200-268-0
56-35-9
yes
201-279-3
80-43-3
Org. Perox. F; Repr. 1B; Skin Irrit. 2; Eye Irrit. 2
216-823-5
1675-54-3
Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
201-245-8
80-05-7
Repr. 1B; STOT SE 3; Eye Dam. 1; Skin Sens. 1
yes
233-139-2
10043-35-3
Repr. 1B
yes
234-343-4
11113-50-1
Repr. 1B
yes
233-657-9
10294-33-4
Acute Tox. 2; Skin Corr. 1A
233-658-4
10294-34-5
Press. Gas; Acute Tox. 2; Skin Corr. 1B
231-569-5
7637-07-2
Press. Gas; Acute Tox. 2; Skin Corr. 1A
249-205-9
28772-56-7
Repr. 1B; Acute Tox. 1; STOT RE 1
232-572-4
9001-00-7
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
231-778-1
7726-95-6
Acute Tox. 2; Skin Corr. 1A
201-175-8
79-08-3
Acute Tox. 3; Skin Corr. 1A; Skin Sens. 1
203-623-8
108-86-1
Flam. Liq. 3; Skin Irrit. 2
200-825-8
74-96-4
Flam. Liq. 2; Carc. 2; Acute Tox. 4
209-800-6
593-60-2
Press. Gas; Flam. Gas 1; Carc. 1B
236-129-6
13181-17-4
Acute Tox. 4
200-854-6
75-25-2
Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
200-813-2
74-83-9
Press. Gas; Muta. 2; Acute Tox. 3; STOT RE 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
218-277-3
2104-96-3
Acute Tox. 4
225-399-0
4824-78-6
Acute Tox. 3; Acute Tox. 4
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2,6-dibromo-4-cyanophenyl octanoate EC / List no: 216-885-3 | CAS no: 1689-99-2
3,5-dibromo-4-hydroxybenzonitrile EC / List no: 216-882-7 | CAS no: 1689-84-5
2,6-dibromo-4-cyanophenyl butyrate EC / List no: 223-374-9 | CAS no: 3861-41-4
2,6-dibromo-4-cyanophenyl heptanoate EC / List no: 260-300-4 | CAS no: 56634-95-8
216-882-7
1689-84-5
Repr. 2; Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
260-300-4
56634-95-8
Repr. 2; Acute Tox. 4; Skin Sens. 1
216-885-3
1689-99-2
Repr. 2; Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
200-143-0
52-51-7
Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
227-317-9
5786-97-0
Acute Tox. 2
225-432-9
4845-99-2
Acute Tox. 2
206-614-7
357-57-3
Acute Tox. 2
208-077-4
507-60-8
Acute Tox. 2
255-391-2
41483-43-6
Carc. 2; Skin Sens. 1B
203-449-2
106-98-9
Flam. Gas 1; Press. Gas
203-788-6
110-65-6
Skin Corr. 1B; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Skin Sens. 1
200-751-6
71-36-3
Flam. Liq. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
203-448-7
106-97-8
Flam. Gas 1; Press. Gas; Carc. 1A; Muta. 1B
203-448-7
106-97-8
Flam. Gas 1; Press. Gas
202-496-6
96-29-7
Carc. 1B; Acute Tox. 4; Acute Tox. 3; STOT SE 3; STOT SE 1; STOT RE 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
201-159-0
78-93-3
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
203-452-9
107-01-7
Flam. Gas 1; Press. Gas
252-139-3
34681-10-2
Flam. Liq. 3; Acute Tox. 3; Eye Irrit. 2
202-318-7
94-26-8
yes
203-656-8
109-21-7
Flam. Liq. 3
209-750-5
592-34-7
Flam. Liq. 3; Acute Tox. 3; Skin Corr. 1B
209-772-5
592-84-7
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
219-376-4
2426-08-6
Flam. Liq. 3; Carc. 2; Muta. 2; Acute Tox. 4; STOT SE 3; Skin Sens. 1
208-862-1
544-16-1
Flam. Liq. 2; Acute Tox. 3
203-699-2
109-73-9
Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
230-358-5
7067-44-9
Acute Tox. 4
204-646-6
123-72-8
Flam. Liq. 2
203-792-8
110-69-0
Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2
203-532-3
107-92-6
Skin Corr. 1B
205-498-5
141-75-3
Flam. Liq. 2; Skin Corr. 1B
204-650-8
123-77-3
Resp. Sens. 1
yes
208-953-6
548-62-9
yes
208-953-6
548-62-9
Carc. 2; Acute Tox. 4; Eye Dam. 1
208-953-6
548-62-9
Carc. 1B; Acute Tox. 4; Eye Dam. 1
220-600-8
2832-40-8
Carc. 2; Skin Sens. 1
212-668-2
842-07-9
Carc. 2; Muta. 2; Skin Sens. 1
208-168-9
513-78-0
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
yes
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cadmium chloride (CdCl2), hydrate (2:5) EC / List no: 640-998-0 | CAS no: 7790-78-5
233-296-7
10108-64-2
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
yes
208-829-1
542-83-6
Acute Tox. 2; Acute Tox. 1; Carc. 2; STOT RE 2
224-729-0
4464-23-7
Acute Tox. 3; Carc. 2; STOT RE 2
232-222-0
7790-79-6
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
yes
244-168-5
21041-95-2
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
yes
232-223-6
7790-80-9
Acute Tox. 3; Carc. 2; STOT RE 2
233-710-6
10325-94-7
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
show/hide
Monteponite (CdO) EC / List no: - | CAS no: 12139-21-8
215-146-2
1306-19-0
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1
yes
show/hide
Sulfuric acid, cadmium salt, hydrate (3:3:8) EC / List no: 616-572-5 | CAS no: 7790-84-3
Sulfuric acid, cadmium salt (1:1), hydrate EC / List no: 626-360-4 | CAS no: 15244-35-6
233-331-6
10124-36-4;31119-53-6
yes
show/hide
Sulfuric acid, cadmium salt (1:1), hydrate EC / List no: 626-360-4 | CAS no: 15244-35-6
Sulfuric acid, cadmium salt, hydrate (3:3:8) EC / List no: 616-572-5 | CAS no: 7790-84-3
233-331-6
10124-36-4;31119-53-6
Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
yes
215-147-8
1306-23-6
Carc. 1B; Muta. 2; Repr. 2; STOT RE 1; Acute Tox. 4
yes
231-152-8
7440-43-9
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1
231-152-8
7440-43-9
yes
231-152-8
7440-43-9
Pyr. Sol. 1; Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2; STOT RE 1
241-084-0
17010-21-8
Acute Tox. 3; Carc. 2; STOT RE 2
200-362-1
58-08-2
Acute Tox. 4
231-179-5
7440-70-2
Water-react. 2
231-904-5
7778-44-1
yes
200-848-3
75-20-7
Water-react. 1
233-140-8
10043-52-4
Eye Irrit. 2
237-366-8
13765-19-0
Carc. 1B; Acute Tox. 4
205-861-8
156-62-7
Acute Tox. 4; STOT SE 3; Eye Dam. 1
209-740-0
592-01-8
Acute Tox. 2
232-189-2
7789-78-8
Water-react. 1
231-908-7
7778-54-3
Ox. Sol. 2; Acute Tox. 4; Skin Corr. 1B
215-142-0
1305-99-3
Water-react. 1; Acute Tox. 2; Acute Tox. 3; Acute Tox. 1; Eye Dam. 1
215-709-2
1344-81-6
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
243-873-5
20548-54-3
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
232-283-3
8001-35-2
Carc. 2; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2
219-363-3
2425-06-1
Carc. 1B; Skin Sens. 1
205-087-0
133-06-2
Carc. 2; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
229-879-0
6804-07-5
Flam. Sol. 1; Carc. 1B; Acute Tox. 4
200-555-0
63-25-2
Carc. 2; Acute Tox. 4
234-232-0
10605-21-7
Muta. 1B; Repr. 1B
240-286-6
16118-49-3
Carc. 2; Repr. 1B; Acute Tox. 4
216-353-0
1563-66-2
Acute Tox. 2
200-843-6
75-15-0
Flam. Liq. 2; Repr. 2; STOT RE 1; Eye Irrit. 2; Skin Irrit. 2
211-128-3
630-08-0
Flam. Gas 1; Press. Gas; Repr. 1A; Acute Tox. 3; STOT RE 1
200-262-8
56-23-5
Carc. 2; Acute Tox. 3; STOT RE 1
240-408-8
16337-84-1
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
212-324-1
786-19-6
Acute Tox. 3
259-565-9
55285-14-8
Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
226-031-1
5234-68-4
STOT RE 2; Skin Sens. 1
239-309-2
15263-52-2
Acute Tox. 4
202-759-5
99-49-0
Skin Sens. 1
253-465-9
37329-65-0
Resp. Sens. 1
232-734-4
9012-54-8
Resp. Sens. 1
206-117-5
302-17-0
Acute Tox. 3; Eye Irrit. 2; Skin Irrit. 2
240-016-7
15879-93-3
Acute Tox. 4; Acute Tox. 3; STOT SE 3
200-349-0
57-74-9
Carc. 2; Acute Tox. 4
205-601-3
143-50-0
Carc. 2; Acute Tox. 3
228-200-5
6164-98-3
Carc. 2; Acute Tox. 4
243-269-1
19750-95-9
Carc. 2; Acute Tox. 4
201-599-3
85-34-7
Acute Tox. 4
201-246-3
80-06-8
Acute Tox. 4
238-413-5
14437-17-3
Acute Tox. 4
201-270-4
80-33-1
Acute Tox. 4; Skin Irrit. 2
207-432-0
470-90-6
Acute Tox. 2; Acute Tox. 3
216-920-2
1698-60-8
Skin Sens. 1
231-959-5
7782-50-5
Ox. Gas 1; Press. Gas; Acute Tox. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
233-162-8
10049-04-4
Press. Gas; Ox. Gas 1; Acute Tox. 2; Skin Corr. 1B
233-162-8
10049-04-4
Acute Tox. 3; Skin Corr. 1B
246-538-1
24934-91-6
Acute Tox. 1; Acute Tox. 2
213-666-4
999-81-5
Acute Tox. 4
203-480-1
107-30-2
Flam. Liq. 2; Carc. 1A; Acute Tox. 4
203-472-8
107-20-0
Carc. 2; Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B
201-178-4
79-11-8
Acute Tox. 3; Skin Corr. 1B
203-467-0
107-14-2
Acute Tox. 3
201-171-6
79-04-9
Acute Tox. 3; STOT RE 1; Skin Corr. 1A
203-628-5
108-90-7
Flam. Liq. 3; Acute Tox. 4; Skin Irrit. 2
208-110-2
510-15-6
Acute Tox. 4
200-431-6
59-50-7
Acute Tox. 4; Skin Corr. 1C; Eye Dam. 1; STOT SE 3; Skin Sens. 1B
247-109-1
25567-67-3
Acute Tox. 3; STOT RE 2
200-830-5
75-00-3
Flam. Gas 1; Press. Gas; Carc. 2
200-663-8
67-66-3
Carc. 2; Repr. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 1; Eye Irrit. 2; Skin Irrit. 2
200-817-4
74-87-3
Flam. Gas 1; Press. Gas; Carc. 2; STOT RE 2
223-003-0
3691-35-8
Repr. 1B; Acute Tox. 1; STOT RE 1
246-691-4
25167-80-0
Acute Tox. 4
204-818-0
126-99-8
Flam. Liq. 2; Carc. 1B; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
232-234-6
7790-94-5
Skin Corr. 1A; STOT SE 3
217-588-1
1897-45-6
Carc. 2; Acute Tox. 2; STOT SE 3; Eye Dam. 1; Skin Sens. 1
246-698-2
25168-05-2
Acute Tox. 4
239-592-2
15545-48-9
Carc. 2; Repr. 2
221-437-5
3091-32-5
Acute Tox. 4
215-316-6
1321-23-9
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
204-105-4
115-78-6
Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
202-925-7
101-21-3
Carc. 2; STOT RE 2
220-864-4
2921-88-2
Acute Tox. 3
227-011-5
5598-13-0
Skin Sens. 1
217-637-7
1918-13-4
Acute Tox. 4
207-902-5
500-28-7
Acute Tox. 4
244-663-6
21923-23-9
Acute Tox. 2; Acute Tox. 3
282-714-4
84332-86-5
Carc. 2
231-801-5
7738-94-5
yes
215-607-8
1333-82-0
Ox. Sol. 1; Carc. 1A; Muta. 1B; Repr. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Skin Corr. 1A; Resp. Sens. 1; Skin Sens. 1
yes
239-056-8
14977-61-8
Ox. Liq. 1; Carc. 1B; Muta. 1B; Skin Corr. 1A; Skin Sens. 1
205-923-4
218-01-9
Carc. 1B; Muta. 2
yes
279-116-0
79234-33-6
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
286-946-7
85407-90-5
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
281-549-5
83968-67-6
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
278-290-5
75660-25-2
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
208-545-8
532-82-1
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
282-432-1
84196-22-5
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
264-409-8
63681-54-9
Muta. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
207-803-7
495-54-5
Muta. 2; Acute Tox. 4; Skin Irrit. 2
232-671-2
9004-07-3
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
246-948-0
25402-06-6
Acute Tox. 4
204-454-2
121-20-0
Acute Tox. 4
216-906-6
1694-82-2
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
213-308-7
935-79-5
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
231-187-9
7443-70-1
Acute Tox. 4
236-086-3
13149-00-3
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
yes
205-859-7
156-59-2
Flam. Liq. 2; Acute Tox. 4
226-394-6
5392-40-5
Skin Irrit. 2; Skin Sens. 1
242-161-1
18283-82-4
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
245-119-0
22605-92-1
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
A complex combination of hydrocarbons produced as the residual fraction from distillation of the products from a catalytic cracking process. It consists of hydrocarbons having carbon numbers predominantly greater than C20 and boiling above approximately 350°C (662°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
265-064-6
64741-62-4
Carc. 1B
A complex combination of hydrocarbons obtained by treating catalytic cracked clarified oil with hydrogen to convert organic sulfur to hydrogen sulfide which is removed. It consists of hydrocarbons having carbon numbers predominantly greater than C20 and boiling above approximately 350°C (662°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
269-782-0
68333-26-6
Carc. 1B
216-935-4
1702-17-6
Eye Dam. 1
204-385-8
120-32-1
Carc. 2; Repr. 2; Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1; Eye Dam. 1; STOT RE 2
231-158-0
7440-48-4
Carc. 1B; Muta. 2; Repr. 1B; Resp. Sens. 1; Skin Sens. 1
208-169-4
513-79-1
Carc. 1B; Muta. 2; Repr. 1B; Resp. Sens. 1; Skin Sens. 1
yes
200-755-8
71-48-7
Carc. 1B; Muta. 2; Repr. 1B; Resp. Sens. 1; Skin Sens. 1
yes
231-589-4
7646-79-9
Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
yes
268-169-5
68016-03-5
Carc. 1A; STOT RE 1; Skin Sens. 1
233-402-1
10141-05-6
Carc. 1B; Muta. 2; Repr. 1B; Resp. Sens. 1; Skin Sens. 1
yes
261-346-8
58591-45-0
Carc. 1A; STOT RE 1; Skin Sens. 1
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77332.
269-051-6
68186-89-0
Carc. 1A; STOT RE 1; Skin Sens. 1
215-154-6
1307-96-6
Acute Tox. 4; Skin Sens. 1
233-334-2
10124-43-3
Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
yes

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