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EC number: 240-383-3 | CAS number: 16291-96-6 An amorphous form of carbon produced by partially burning or oxidizing wood or other organic matter.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- other: Publication
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
- Principles of method if other than guideline:
- no further data available from the publication
- GLP compliance:
- not specified
- Remarks:
- no further data available from the publication
- Limit test:
- no
Test material
- Reference substance name:
- Activated charcoal
- IUPAC Name:
- Activated charcoal
- Test material form:
- not specified
- Details on test material:
- no further data available from the publication
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 2 month-old female mice (24 g average, three mice per group)
Administration / exposure
- Route of administration:
- other: intravenous and intraperitonial
- Vehicle:
- not specified
- Details on exposure:
- injected intravenously with increasing quantities of the charcoal suspension in a volume of 0.1 ml: 20/xg (0.83 mg/kg), 40/xg (1.66 mg/kg), 400/zg (16.6 mg/kg) and 4 mg (166 mg/kg)
- Doses:
- not further data available from the publication
- No. of animals per sex per dose:
- not further data available from the publication
- Control animals:
- not specified
- Details on study design:
- not further data available from the publication
- Statistics:
- no further data available from the publication
Results and discussion
- Mortality:
- micronized activated charcoal caused no death of mice tested
- Clinical signs:
- no further data available from the publication
- Body weight:
- no further data available from the publication
- Gross pathology:
- no further data available from the publication
- Other findings:
- Intravenous injection of 166 mg/kg b.w. of activated charcoal caused instantaneous death of animals tested.
Intraperitoneal administration of 166 mg/kg b.w. of micronized activated charcoal caused no death of mice tested.
Acute toxicity observed only if large amounts of charcoal are directly indroduced into the circulation.
Any other information on results incl. tables
no further data available from the publication
Applicant's summary and conclusion
- Conclusions:
- Intravenous injection of 166 mg/kg b.w. of activated charcoal caused instantaneous death of animals tested.
Intraperitoneal administration of 166 mg/kg b.w. of micronized activated charcoal caused no death of mice tested.
Acute toxicity observed only if large amounts of charcoal are directly indroduced into the circulation. - Executive summary:
In the study of Bonhomme-Falvre et al.(1996) to determine the in vivo lethal dose 50 (LD50) of a micronized peat charcoal (Norit) suspension, 2 month-old female mice (24 g average, three mice per group) were injected intravenously with increasing quantities of the charcoal suspension in a volume of 0.1 ml: 20/xg (0.83 mg/kg), 40/xg (1.66 mg/kg), 400/zg (16.6 mg/kg) and 4 mg (166 mg/kg). Surviving mice were killed at the following times: 3 hours, 24 hours, days 22 and 60 and autopsied. Intravenous injection of 166 mg/kg b.w. of activated charcoal caused instantaneous death of animals tested. Intraperitoneal administration of 166 mg/kg b.w. of micronized activated charcoal caused no death of mice tested. According to the study authors, acute toxicity is observed only if large amounts of charcoal are directly indroduced into the circulation.
It is noted that both routes of exposure studied by Bonhomme-Falvreet al.(1996) are not relevant for the examined charcoal and the intended use pattern. However, the significant difference noted following the intraperitoneal and intravenous exposure to activated charcoal supports the fact that the systematic absorption of charcoal (at least in terms of fix carbon content) is limited when administered via the dermal route.
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