Registration Dossier

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: publication
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1962

Materials and methods

Objective of study:
not specified
Principles of method if other than guideline:
no data available from the publication
GLP compliance:
not specified
Remarks:
no data available from the publication

Test material

Constituent 1
Reference substance name:
Carbon black
EC Number:
215-609-9
EC Name:
Carbon black
Cas Number:
1333-86-4
IUPAC Name:
methane
Test material form:
not specified
Details on test material:
no data available from the publication
Radiolabelling:
not specified
Remarks:
no data available from the publication

Test animals

Species:
other: no data available from the publication
Strain:
other: no data available from the publication
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data available from the publication

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Remarks:
no data available from the publication
Details on exposure:
no data available from the publication
Duration and frequency of treatment / exposure:
no data available from the publication
Doses / concentrations
Remarks:
Doses / Concentrations:
no data available from the publication
No. of animals per sex per dose / concentration:
no data available from the publication
Control animals:
not specified
Positive control reference chemical:
no data available from the publication
Details on study design:
no data available from the publication
Details on dosing and sampling:
no data available from the publication
Statistics:
no data available from the publication

Results and discussion

Preliminary studies:
no data available from the publication

Toxicokinetic / pharmacokinetic studies

Details on absorption:
no data available from the publication
Details on distribution in tissues:
no data available from the publication
Details on excretion:
no data available from the publication

Metabolite characterisation studies

Metabolites identified:
not specified
Details on metabolites:
no data available from the publication

Bioaccessibility (or Bioavailability)

Bioaccessibility (or Bioavailability) testing results:
no data available from the publication

Any other information on results incl. tables

no data available from the publication

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
There have not been reports of gastroinestinal absorption and carbon black is probably cleared in faeces following oral administration.
Executive summary:

There have not been reports of gastroinestinal absorption and carbon black is probably cleared in faeces following oral administration.