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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

A study is scientifically unjustified. 

Key value for chemical safety assessment

Additional information

A chronic toxicity test on fish does not need to be conducted due to the facts that
  • the substance is not classified according to 67/548/EEC
  • the substance is readily biodegradable according to OECD criteria
  • the substance does not have a potential to bioaccumulate nor is it considered as a PBT/vPvB substance.
Therefore, and for reasons of animal welfare, a chronic test on fish is not provided.


Under neutral conditions (pH 7) at 20 °C methyl formate is expected to undergo hydrolysis with a half-live of ca. 2 days (BASF, 2010). The products of this hydrolytic reaction are formic acid and methanol. Both products are not classified according to 67/548/EEC, are readily biodegradable and have no potential to bioaccumulate.

Hydrolysis product formic acid/formate

With formic acid a 21 -day chronic toxicity test withDaphnia magna is available, performed according to OECD TG 211. The NOEC based on reproduction and growth was determined to be 100 mg/L, indicating no adverse long-term effects (OECD TG 211; BASF AG, 2007).


Hydrolysis product methanol

In an early-life-stage bioassay conducted with Oryzias latipes (Gonzales-Doncel et al., 2008), NOECs range between 7900 - 15800 mg/L. Although this in-vitro study was not conducted according to current standard guidelines, the results give a clear indication of the low hazard potential (acute and long-term) of methanol to aquatic organisms.