Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: clinical case report
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Gettler AO
Year:
1940
Bibliographic source:
Am J Clin Path 10, 188-190.
Reference Type:
publication
Title:
The aliphatic acids and their esters - toxicity and potential dangers.
Author:
von Oettingen WF
Year:
1959
Bibliographic source:
Arch Ind Health 20, 517-531.

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
dermal absorption
Principles of method if other than guideline:
not applicable
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
parasiticide, evidently containing methyl formate

Method

Type of population:
general
Subjects:
- Number of subjects exposed: 1
- Age: 19 months
Ethical approval:
not applicable
Remarks:
clinical case report
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
A fatal case of methyl formate poisoning in a 19-months old child was reported whose scalp had been treated with a parasiticide, evidently containing methyl formate, and subsequently covered for 20 min with a rubber cap.
Examinations:
Post mortem determination of methyl formate in brain and liver.

Results and discussion

Clinical signs:
 When the cap was removed after 20 minutes, the child collapsed, became cyanotic, and breathed slowly.
Results of examinations:
Methyl formate was found to be present in the brain. After hydrolysis to methanol, the methyl formate tissue burden was calculated to be 236 mg/kg in brain and 220 mg/kg in liver.
Effectivity of medical treatment:
No effective treatment
Outcome of incidence:
The child died from cardiac arrest. Brain, lings, liver, kidneys, and spleen were found highly congested.

Applicant's summary and conclusion

Executive summary:

Methyl formate may be dermally absorbed.