Triphenyl phosphate

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vitro / ex vivo

Type of information:

experimental study

Reliability:

4 (not assignable)

Data source

Reference

Reference Type:

publication

Title:

Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model

Author:

Frederiksen M et al

Year:

2018

Bibliographic source:

Chemosphere 197 (2018) 185-192

Materials and methods

Principles of method if other than guideline:

no guideline followed

Test material

Test material information

Constituent 1

Reference substance name:

Triphenyl phosphate

EC Number:

204-112-2

EC Name:

Triphenyl phosphate

Cas Number:

115-86-6

Molecular formula:

C18H15O4P

IUPAC Name:

triphenyl phosphate

Radiolabelling:

no

Results and discussion

Any other information on results incl. tables

Dermal uptake and percutaneous penetration of the OPEs were studied in a Franz diffusion cell system using human skin dosed with a mixture of OPEs in an ethanol: toluene (4:1) solution. Large variation in penetration profiles was observed between the OPEs. The chlorinated OPEs tris(2-chloroisopropyl) phosphate (TCIPP), and in particular tris(2-chloroethyl) phosphate (TCEP), penetrated the skin quite rapidly while tris(1,3-dichlor-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP) tended to build up in the skin tissue and only smaller amounts permeated through the skin. The rates at which OPEs permeated through the skin decreased in the order TCEP > TCIPP _ TBOEP > TIBP _ TNBP > TDCIPP > TPHP > TMPP. Generally, the permeation coefficient, kp, decreased with increasing log Kow, whereas lag time and skin deposition increased with log Kow.