Registration Dossier
Registration Dossier
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EC number: 204-112-2 | CAS number: 115-86-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: It is well documented and scientifically acceptable. Also assessed by OECD.
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of Phosphoric Acid Triesters by Rat Liver Homogenate
- Author:
- Sasaki K, Suzuki T, Takeda M, Uchiyama M
- Year:
- 1 984
- Bibliographic source:
- Bull Environ Contam Toxicol 33 (3), 281-288
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Method: C36-001:
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Triphenyl phosphate
- EC Number:
- 204-112-2
- EC Name:
- Triphenyl phosphate
- Cas Number:
- 115-86-6
- Molecular formula:
- C18H15O4P
- IUPAC Name:
- triphenyl phosphate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Rats used weighed between 150-200g.
Administration / exposure
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Rat livers were removed and the microsomal and soluble fractions extracted. An ethanol solution of TPP at 0.0004M was used as substrate to determine the extent of decomposition by the fractions with and without NADPH and other enzyme systems. Major metabolites resulting from TPP degradation were characterised using gas chromotography.
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 3rd:
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Diphenyl phosphate (DPP) was the only major metabolite of TPP.
Applicant's summary and conclusion
- Conclusions:
- TPP is degraded by hydrolysis in rat liver homogenate to diphenyl phosphate (DPP) as the major product.
- Executive summary:
Investigation to obtain basic data on the metabolic transformation of TPP, the decomposition of TPP in vitro by rat liver preparation was examined and the effects of coenzymes and inhibitors on the metabolism were investigated to elucidate the predominant enzyme reaction involved. The results showed that TPP was decomposed to diphenyl phosphate (DPP) by both MFO and arylesterase in microsomes.
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