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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Short report, few details. Also assessed by OECD

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Method: other: as described in 16 CFR 1500.40
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Triphenyl phosphate
EC Number:
204-112-2
EC Name:
Triphenyl phosphate
Cas Number:
115-86-6
Molecular formula:
C18H15O4P
IUPAC Name:
triphenyl phosphate

Test animals

Species:
rabbit
Strain:
other: Albino
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
This study was conducted according to US Federal Hazardous Substances Act Regulations study guideline 16 CFR 1500.40. 5 rabbits were tested with intact skin and 5 with abraded skin. Observation period of 14 days.
Doses:
10000 mg/kg
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Mortality:
None
Clinical signs:
other: No data
Gross pathology:
No data

Any other information on results incl. tables

MORTALITY: none

Applicant's summary and conclusion

Interpretation of results:
not classified
Conclusions:
Dermal LD50 is > 10,000 mg/kg body weight.
Executive summary:

2 groups of 5 albino rabbits were treated each with a dose of 10 000 mg/kg body weight on either intact or abraded skin. No adverse effects nor mortality were observed during 14 -days post-exposure. The LD50 is >10,000 mg/kg body weight.