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Registration Dossier
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EC number: 204-112-2 | CAS number: 115-86-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro DNA damage and/or repair study
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: detailed description of testsystem given. Also assessed by OECD.
Data source
Reference
- Reference Type:
- other: Thesis
- Title:
- Beziehungen zwischen neurotoxischer, mutagener und kanzerogener Wirkung organischer Phosphorverbindungen - Entwicklung und Validierung eines Zellkulturverfahrens zur Voraussage neurotoxischer Effekte.
- Author:
- Schmuck G
- Year:
- 1 989
- Bibliographic source:
- Thesis, University of Würzburg, Germany
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 482 (Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells In Vitro)
- GLP compliance:
- not specified
- Type of assay:
- DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro
Test material
- Reference substance name:
- Triphenyl phosphate
- EC Number:
- 204-112-2
- EC Name:
- Triphenyl phosphate
- Cas Number:
- 115-86-6
- Molecular formula:
- C18H15O4P
- IUPAC Name:
- triphenyl phosphate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Syrian hamster embryonic fibroblast cells (SHE)
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 0.1 - 10x E-5 M
- Details on test system and experimental conditions:
- Unscheduled DNA synthesis
Results and discussion
Test results
- Species / strain:
- other:
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: Test system: Syrian hamster embryonic fibroblast cells (SHE)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative without metabolic activation
TPP was negative in inducing unscheduled DNA synthesis. - Executive summary:
Unscheduled DNA synthesis was examined in Syrian hamster fibroblast cells at concentrations of 0.05 to 10 x 10 -5 M. After 5 hours of incubation without metabolic activation in the presence of 3H-thymidine. TPP showed no genotoxic effect.
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