Registration Dossier
Registration Dossier
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EC number: 204-112-2 | CAS number: 115-86-6
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity, other
- Remarks:
- other:
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: high purity test substance, low animal number. Also assessed by OECD.
Data source
Reference
- Reference Type:
- publication
- Title:
- Does triphenyl phosphate produce delayed neurotoxic effects?
- Author:
- Wills JH, Barron K, Groblewski GE, Benitz KF, Johnson MK
- Year:
- 1 979
- Bibliographic source:
- Toxicology Letters 4(1), 21-24
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- not specified
- Principles of method if other than guideline:
- Neurotoxicity study in cats. Low animal number.
- Limit test:
- no
Test material
- Reference substance name:
- Triphenyl phosphate
- EC Number:
- 204-112-2
- EC Name:
- Triphenyl phosphate
- Cas Number:
- 115-86-6
- Molecular formula:
- C18H15O4P
- IUPAC Name:
- triphenyl phosphate
Constituent 1
Test animals
- Species:
- cat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Subcutaneous, single dose,
- Frequency of treatment:
- single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
400, 700 and 1000 mg/kg bw
Basis:
no data
- No. of animals per sex per dose:
- 8 animals
Results and discussion
Any other information on results incl. tables
OBSERVATION:
400 mg/kg bw: no ataxia
700 mg/kg bw: weight loss, prostration, diarrhea
1000 mg/kg bw: weight loss, prostration,
Histopathology (700 mg/kg): generalized vascular damage, perivascular edema, loss of colon epithelium, fatty change in the liver
HISTOPATHOLOGY OF NERVOUS TISSUES:
no axon degeneration or demyelination or any other pathological change at any dose level.
Applicant's summary and conclusion
- Conclusions:
- There was weight loss at the mid and high dose groups but not evidence of neurotoxicity following histological examination of nervous tissues.
- Executive summary:
Cats administered s.c single dose of TPP (400, 700, 1000 mg/kg bw) exhibited the following:
OBSERVATION:
400 mg/kg bw: no ataxia
700 mg/kg bw: weight loss, prostration, diarrhea
1000 mg/kg bw: weight loss, prostration,
Histopathology (700 mg/kg): generalized vascular damage, perivascular edema, loss of colon epithelium, fatty change in the liver
HISTOPATHOLOGY OF NERVOUS TISSUES:
no axon degeneration or demyelination or any other pathological change at any dose level.
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