Triphenyl phosphate

Neurotoxicity

Administrative data

Endpoint:

neurotoxicity, other

Remarks:

other:

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: high purity test substance, low animal number. Also assessed by OECD.

Data source

Reference

Reference Type:

publication

Title:

Does triphenyl phosphate produce delayed neurotoxic effects?

Author:

Wills JH, Barron K, Groblewski GE, Benitz KF, Johnson MK

Year:

1979

Bibliographic source:

Toxicology Letters 4(1), 21-24

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Deviations:

not specified

Principles of method if other than guideline:

Neurotoxicity study in cats. Low animal number.

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triphenyl phosphate

EC Number:

204-112-2

EC Name:

Triphenyl phosphate

Cas Number:

115-86-6

Molecular formula:

C18H15O4P

IUPAC Name:

triphenyl phosphate

Test animals

Species:

cat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

subcutaneous

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

Subcutaneous, single dose,

Frequency of treatment:

single dose

Doses / concentrations

Remarks:

Doses / Concentrations:
400, 700 and 1000 mg/kg bw
Basis:
no data

No. of animals per sex per dose:

8 animals

Results and discussion

Any other information on results incl. tables

OBSERVATION: 
400 mg/kg bw: no ataxia
700 mg/kg bw: weight loss, prostration, diarrhea
1000 mg/kg bw: weight loss, prostration, 
Histopathology (700 mg/kg): generalized vascular damage, perivascular  edema, loss of colon epithelium, fatty change in the liver

HISTOPATHOLOGY OF NERVOUS TISSUES: 
no axon degeneration or demyelination or any other pathological change at  any dose level.

Applicant's summary and conclusion

Conclusions:

There was weight loss at the mid and high dose groups but not evidence of neurotoxicity following histological examination of nervous tissues.

Executive summary:

Cats administered s.c single dose of TPP (400, 700, 1000 mg/kg bw) exhibited the following:

OBSERVATION: 
400 mg/kg bw: no ataxia
700 mg/kg bw: weight loss, prostration, diarrhea
1000 mg/kg bw: weight loss, prostration, 
Histopathology (700 mg/kg): generalized vascular damage, perivascular  edema, loss of colon epithelium, fatty change in the liver
HISTOPATHOLOGY OF NERVOUS TISSUES: 
no axon degeneration or demyelination or any other pathological change at  any dose level.