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EC number: 204-112-2
CAS number: 115-86-6
A study was performed to assess the contact sensitisation potential of
TPP in guinea pigs according to OECD guidelines study 406. Ten test and
five control animals were used for the study. Two phases were involved
in the main study; an induction of a response by intradermal injection
and topical application and a topical challenge of that response. Based
on sighting tests, the concentrations of TPP for the induction and
challenge phases were selected as:
Intradermal induction: 5%w/w in arachis oil; Topical Induction: 75%w/w
in arachis oil; Topical challenge 75 and 50%w/w in arachis oil. The
results showed that TPP produced a 0% (0/10) sensisitisation rate and
classified as a non-sensitiser to guinea pig skin.
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