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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: case report. No details about exposure concentrations and duration. Also assessed by OECD.

Data source

Reference
Reference Type:
publication
Title:
Contact dermatitis from plastic containing triaryl phsophates.
Author:
Pegum JS
Year:
1966
Bibliographic source:
Brit. J. Derm. 78: 626-631

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Triphenyl phosphate
EC Number:
204-112-2
EC Name:
Triphenyl phosphate
Cas Number:
115-86-6
Molecular formula:
C18H15O4P
IUPAC Name:
triphenyl phosphate

Method

Type of population:
not specified
Ethical approval:
not specified
Subjects:
- Number of subjects exposed: 1
- Other: no other data
Clinical history:
- History of allergy or casuistics for study subject or populations: dermatitis
no other data
Route of administration:
dermal
Details on study design:
One person with mutiple causes producing dermatitis was patched with TPP and other aryl phosphates.

Results and discussion

Results of examinations:
Person tested positive to all patches.

Applicant's summary and conclusion

Conclusions:
Positive to all patches.
Executive summary:

One person with multiple causes producing dermatitis was patched with TPP and other aryl phosphates. The person tested positive to all patches.