Triphenyl phosphate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Exposure level lower than recommended for a limit test, chamber closed, not according to guideline, observation period inadequate. Also assessed by OECD.

Data source

Reference

Reference Type:

publication

Title:

Studies on the industrial hygiene and toxicology of triphenyl phosphate.

Author:

Sutton WL, Terhaar CJ, Miller FA, Scherberger RF, Riley EC, Roudabush RL, Fassett DW

Year:

1960

Bibliographic source:

Arch. Environ. Health 1, 45-58

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

exposure level lower than recommended, closed chamber

Principles of method if other than guideline:

Mice exposed to TPP vapour in a battery jar.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Triphenyl phosphate

EC Number:

204-112-2

EC Name:

Triphenyl phosphate

Cas Number:

115-86-6

Molecular formula:

C18H15O4P

IUPAC Name:

triphenyl phosphate

Test animals

Species:

mouse

Strain:

CF-1

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Analytical verification of test atmosphere concentrations:

not specified

Concentrations:

363 mg/m3 for 6 hours, 5 mice and 757 mg/m3 for 2 and 4 hours, 7mice/ducration

Control animals:

yes

Results and discussion

Any other information on results incl. tables

None of the animals exhibited any colinergic signs or symptoms.
No significant effects at 363 mg/m3(6h) and 757 mg/m3(4 h)
significant effect at 757 mg/m3 (2h) but with questionable biological relevance

The mice were observed for signs of cholinergic toxicity and blood chloinesterase was measured at termination but were considered not valid because controls did not appear to have been sham exposed.

Applicant's summary and conclusion

Interpretation of results:

other: practically nontoxic

Remarks:

expert judgment

Conclusions:

No overt signs of toxicity; Cholinesterase determinations not considered valid as controls did not appear sham exposed.

Executive summary:

In an acute inhalation study, mice were exposed to TPP vapour in a battery jar following generation of the vapour by flowing preheated air through molten TPP at 175 -180 deg C. Observation period was 24 hours. The mice were observed for signs of cholinergic toxicity and blood cholinesterase was measured at termination. No overt signs of toxicity; cholinesterase determinations not considered valid because the controls did not appear to be sham exposed.