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EC number: 910-757-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Particle size distribution (Granulometry)
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
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- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals
- Deviations:
- no
- Remarks:
- Not specified
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Reaction mass of divinylbenzene and ethylstyrene
- EC Number:
- 910-757-7
- Cas Number:
- N/A
- Molecular formula:
- Divinylbenzene: C10H10 Ethylstyrene: C10H12
- IUPAC Name:
- Reaction mass of divinylbenzene and ethylstyrene
- Details on test material:
- Source: Nippon Steel Chem.
Purity; 96.2%
Constituent 1
Method
- Target gene:
- TA100- hisG46 , TA1535- hisG46, TA98- hisD3052, TA1537-hisC3076, Escherichia coli WP2uvr A- trp
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix: Rat liver, induced with phenobarbital and 5.6-benzoflavone
- Test concentrations with justification for top dose:
- -S9 mix; 0, 0.781, 1.56, 3.13, 6.25, 12.5, 25.0, 50.0 ug/plate (TA1535 (Test 1));
0, 1.56 - 50.0 ug/plate (TA1535 (Test 2));
0, 3.13 - 100 ug/plate (TA100, TA98, TA1537);
0, 6.25 - 200 ug/plate (WP2 uvrA)+S9 mix;
0, 6.25 -200ug/plate (TA100, TA1535, TA98, TA1537) - Vehicle / solvent:
- No data
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- Positive controls:
- not specified
- Details on test system and experimental conditions:
- -S9 mix; 0, 0.781, 1.56, 3.13, 6.25, 12.5, 25.0, 50.0
ug/plate (TA1535 (Test 1)); 0, 1.56 - 50.0 ug/plate (TA1535
(Test 2)); 0, 3.13 - 100 ug/plate (TA100, TA98, TA1537); 0,
6.25 - 200 ug/plate (WP2 uvrA)+S9 mix; 0, 6.25 -200ug/plate
(TA100, TA1535, TA98, TA1537)
S9: Rat liver, induced with phenobarbital and
5.6-benzoflavone.
Plate/test; 3
Number of replicates; 2 - Evaluation criteria:
- No data
- Statistics:
- No data
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Positive controls validity:
- not specified
- Key result
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Toxicity was observed at 50.0 ug/plate (TA100, TA1535, TA1537) and 100 ug/plate (TA98, WP2 urvA) without an S9 mix, and at 100 ug/plate (TA100, TA1535, TA98, TA1537) and 250 ug/plate (WP2 urvA) with an S9 mix.
Any other information on results incl. tables
The authors concluded that DVB was negative in this reverse mutation test, although styrene oxide which was structurally related to DVB was reported to be positive in the bacterial reverse mutation test and in the chromosomal aberration test, and negative in the micronucleus test on mice.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
DVB did not induce gene mutations in S. typhimurium or E. coli strains with and without metabolic activation - Executive summary:
The study was conducted according to the Guidelines for screening mutagenicity testing of chemicals, JAPAN. DVB did not induce gene mutations in S. typhimurium or E. coli strains with and without metabolic activation.
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