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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study planned
Study period:
within 18 months of the final decision
Justification for type of information:
study is a mandatory requirement for substances >1000t. There are very limited opportunities to waive the study.

- Available GLP studies - none
- Available non-GLP studies - none
- Grouping and read-across - not appropriate
- Historical human data - none
- (Q)SAR - not valid for this endpoint
- In vitro methods - not valid for this endpoint
- Weight of evidence - no studies with which to form weight of evidence
- Substance-tailored exposure driven testing [if applicable] - not appropriate for this endpoint considering the uses and the extremely limited circumstances where an exposure base waiving argument is acceptable

Data source

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 414 (Prenatal Developmental Toxicity Study)

Test material

Constituent 1
Chemical structure
Reference substance name:
Divinylbenzene
EC Number:
215-325-5
EC Name:
Divinylbenzene
Cas Number:
1321-74-0
Molecular formula:
C10H10
IUPAC Name:
Benzene, diethenyl-
Constituent 2
Chemical structure
Reference substance name:
Ethylstyrene
EC Number:
248-846-1
EC Name:
Ethylstyrene
Cas Number:
28106-30-1
Molecular formula:
C10H12
IUPAC Name:
Benzene, ethenylethyl-
Test material form:
liquid
Details on test material:
Exact composition of test material to be agreed with other registrants based on what is the most representative composition

Test animals

Species:
rabbit

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Results (fetuses)

Fetal abnormalities

Key result
Abnormalities:
not specified

Overall developmental toxicity

Key result
Developmental effects observed:
not specified

Applicant's summary and conclusion