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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of divinylbenzene and ethylstyrene
EC Number:
910-757-7
Cas Number:
N/A
Molecular formula:
Divinylbenzene: C10H10 Ethylstyrene: C10H12
IUPAC Name:
Reaction mass of divinylbenzene and ethylstyrene
Details on test material:
Vapor phase chromatograph (VPC) analysis :
Divinylbenzene 55.7%, Ethylvinylbenzene 40.4%, Diethylbenzene 4.5%, Mass 144-146 1.7%, Naphthalene 0.4%, t-Butyl Catechol 1010 ppm, Polymer 4 ppm

The percentage was determined by measuring the percent area of each component shown in the vapor phase chromatograph and is
considered to be approximately equal to weight percent.


Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
To establish the acute oral lethality, varying amounts of the undiluted liquid material were administered to female rats by single dose gavage after an 18-hour food deprivation period.
Doses:
0.5, 1.0, 2.0, 3.98, 7.95 g/kg
No. of animals per sex per dose:
5 female rats/dose
Control animals:
no
Details on study design:
To establish the acute oral lethality, varying amounts of the undiluted liquid material were administered to female rats by single dose gavage after an 18-hour food deprivation period. The animals were weighed before dosing, the day following and at weekly intervals for 2 weeks thereafter and were observed periodically for signs of toxicity.
Statistics:
No data

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 3.98 - < 7.95 other: g/kg
Remarks on result:
other: An approximate graphical analysis showed that the value is 4.1 g/kg body weight.
Mortality:
5/5 at 7.95 g/kg, 1/5 at 3.98 g/kg and 0/5 for 2.0, 1.0 and 0.5 g/kg
Clinical signs:
other: other: other: Rats given 3.98 or 7.95 g/kg were inactive and fur stained with urine during the first 48 hours after treatment. Death was observed two days after treatment for animals given 7.95 g/kg.
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The single dose oral LD50 for DVB-55 in female rats is between 3.98 and 7.95 g/kg body weight. An approximate graphical analysis showed that the value is 4.1 g/kg body weight.
Executive summary:

Female rats were given a single gavage administration of the test substances at doses of 0.5, 1.0, 2.0, 3.98, and 7.95 g/kg and were observed for 14 days. Rats given 3.98 or 7.95 g/kg were inactive and fur stained with urine during the first 48 hours after treatment. Death was observed two days after treatment for animals given 7.95 g/kg. The single dose oral LD50 in female rats is between 3.98 and 7.95 g/kg body weight.  An approximate graphical analysis showed that the value is 4.1 g/kg body weight.