Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

GLP-studies according to OECD guideline 209 are available for different grades of the reaction mass of divinylbenzene and ethylstyrene.

Key value for chemical safety assessment

EC50 for microorganisms:
190 mg/L
EC10 or NOEC for microorganisms:
50 mg/L

Additional information

Two studies on toxicity to microorganisms are available for the reaction mass of divinylbenzene and ethylstyrene one conducted with DVB-55 (reaction mass of approximately 55% divinylbenzene and 45% ethylstyrene) and one conducted with DVB-HP (reaction mass of approximately 80% divinylbenzene and 20% ethylstyrene). Both key studies were conducted under GLP and according to OECD guidelines 209. Due to the volatile nature of the test material, the test duration was reduced from 3 hours as specified in the Test Guidelines to 30 minutes as it was considered likely that any longer test duration would result in significant losses of test material from the test system. The DVB-HP grade proved to be more toxic to microorganisms in comparison to DVB-55. The 30 min EC50 for DVB-55 was 380 mg/L, while the 30 min EC50 for DVB-HP was 190 mg/L, the NOECs in these studies were 100 mg/L and 50 mg/L, respectively. No data is available for DVB-63 (reaction mass of approximately 63% divinylbenzene and 37% ethylstyrene). However, as higher concentrations of each of the components are present in the grades tested (DVB-55 and DVB-HP), the toxicity of both components of this reaction mass has been sufficiently investigated by the studies conducted on those grades.