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EC number: 204-464-7
CAS number: 121-32-4
Available studies were poorly detailed, but gave negative results.
In the study of Hagan (1967), rats (12 males and 12 females per group) were exposed by feeding for 2 years to 5000,10000 and 20000 ppm (250, 500 and 1000 mg/kg/day). Only few results were reported with no details, it appears no effect (general and carcinogenic effects) for all the doses tested.
Despite the fact that only few results were reported, this study shows that ethylvanillin has low toxicity and carcinogenic effects were not expected.
Two studies were available, one performed by oral route with reliability 2 according to Klimisch (Hagan, 1967) and another one conducted by i.p. with reliability 4 (Stoner, 1973).
These studies were poorly described, but gave negative results.
Based on the first study with reliability 2 and performed by oral route (selected as key study), ethylvanillin appears to have low toxicity and carcinogenic effects were not expected even if all the organs were not examined.
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