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EC number: 204-464-7
CAS number: 121-32-4
Table 2: Mortalities observed in each
Initial n° of fish in each exposure chamber
In a 96-h acute toxicity study (Brooke, 1984), Fathead Minnows (Pimephales promelas) were exposed to ethyl vanillin at nominal concentrations of 0 (control); 12.5; 25; 50; 100 & 200 mg/L under flow through conditions.
The 96-h LC50 was 87.6 mg a.i./L. 95% C.I.: 81.4 to 94.3 mg/L (based on measured concentrations).
Based on the criteria of the CLP regulation, Ethylvanillin is considered as harmful for Pimephales promelas in the conditions tested.
Although GLP were not mentionned and validity criteria not detailled, this toxicity study satisfies the guideline requirement and is therefore considered as reliable with restrictions.
Ethylvanillin was forced fed to fish and
behaviour and death were recorded during a minimum of 44 hours.
The administration of 205 to 222 mg/L do not
induce any toxicity to the fishes.
Ethylvanillin is not considered harmful to
fish, under these conditions.
The 96-hour LC50 of test item to Pimephales promelas was determined to be 87.6 mg/L.
Two studies were assigned a Klimisch score of 2. One of them, done in accordance with the recognized guidelines, was selected as key study, and its summary is the following:
In a 96-h acute toxicity study (Brooke, 1984), fathead minnows (Pimephales promelas) were exposed to ethylvanillin at nominal concentrations of 0 (control); 12.5; 25; 50; 100 and 200 mg/L under flow through conditions.
The 96-h LC50 was 87.6 mg/L. 95% C.I. (Confidence Interval): 81.4 to 94.3 mg/L (based on measured concentrations).
Based on the criteria of the CLP regulation, ethylvanillin is considered as harmful for Pimephales promelas.
Although GLP were not mentioned and validity criteria not detailed, this toxicity study satisfies the guideline requirement and is therefore considered as reliable with restrictions.
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