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EC number: 204-464-7
CAS number: 121-32-4
irritant/corrosive response data for each animal at each observation
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time (unit) for reversion
*) Reversibility: c. =
completely reversible; n.c.=
not completely reversible; n. = not reversible
one primary eye irritation study of
validity 1 (Klein, 2003), 100 mg of ethylvanillin was instilled into the
conjunctival sac of left eye of young adult New Zealand White rabbits (3
animals). Eyes were not rinsed and the right eye served as control.
Animals then were observed for 7 days.
was scored by the method according to the Commission Directive
2004/73/EC. Mean scores calculated for each animal over 24, 48 and 72
hours were 2.3, 1.3 and 1.3 for chemosis, 2.7, 1 and 1.3 for redness of
the conjunctivae, 1, 0 and 0 for iris lesions and 1.3, 1 and 0.7 for
this study, ethylvanillin was slightly eye irritant and based on the EU
classification criteria (1272/2008) it should be classified as Eye irri.
category 2 (H319).
is not classified according to the 67/548/EC directive criteria.
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