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EC number: 204-464-7
CAS number: 121-32-4
Oral LD50 > 3160 mg/kgDermal LD 50 > 2000 mg/kg
In a study (Hazleton, 1992), Sprague-Dawley rats (5M/5F/dose) received ethylvanillin at different doses of 2000, 2510 and 3160 mg/kg in vehicle carboxymethylcellulose (CMC).
Animals were observed for 14 days.
Clinical signs: subdued behaviour and lethargy were noted at 15 min, 1, 2, 4 hours after treatment. All animals were normal on day 2 for the 3 tested doses.
No mortality was observed.
The LD50 was higher than 3160 mg/kg.
In these conditions, ethylvanillin is not classified as harmful by ingestion according to EU GHS criteria.
one acute dermal toxicity study of validity 1 (Hazleton,
1992), groups of Sprague-Dawley rats (5 males / 5 females per group)
were dermally exposed to ethylvanillin for 24 hours at doses of 2000
vehicle used was purified water. Animals then were observed for 14 days.
signs: no pathological signs were noted at 2000 mg/kg and no mortality
was higher than 2000 mg/kg.
on these results, Ethylvannilin is not considered harmful by contact
Four studies were available. One with reliability 1 according to Klimish scale was selected as the key study. In this key study (Lheritier -1992), Sprague-Dawley rats (5M/5F/dose) received ethylvanillin at different doses 2000, 2510 and 3160 mg/kg in vehicle carboxymethylcellulose (CMC). Animals were observed for 14 days. Clinical signs: subdued behaviour and lethargy were noted at 15 min, 1, 2, and 4 h after treatment. All animals were normal on day 2 for the 3 tested concentrations.No mortality was observed.
The LD50 was > 3160 mg/kg. Based on this value and according to the EU classification criteria, ethylvanillin is not classified for oral acute toxicity.
Only one study was available and selected as key study and has the reliability 1 according to Klimish.
In this acute dermal toxicity study (Hazleton, 1992), groups of young Sprague-Dawley rats (5/sex) were dermally exposed to ethylvanillin (assumed to be 100%) moistened with purified water for 24 hours to 10% of body surface area at dose of 2000 mg/kg bw. Animals then were observed for 14 days.
Dermal LD50 Combined > 2000 mg/kg bw. Neither mortality nor clinical signs were observed at this dose.
According to the EU classification criteria, ethyvanillin is not classified for dermal acute toxicity based on the dermal LD50 higher than 2000 mg/kg bw.
Based on available studies, ethylvanillin is not classified for acute oral and dermal toxicity according to the CLP 1272/2008/EC classification criteria.
Based on these same studies, since no adverse effect were observed, ethylvanillin is not classified as STOT single exposure, according to CLP 1272/2008/EC criteria.
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