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EC number: 204-464-7 | CAS number: 121-32-4
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Toxicological Summary
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- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Non conventional patch test with only one woman exposed, who presented allergic reaction to eau de toilette. The ethylvanillin tested was extracted from eau de toilette.
Data source
Reference
- Reference Type:
- publication
- Title:
- Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix.
- Author:
- Mutterer V, Gimenez-Arnau E, Lepoittevin JP, Johansen JD, Frosch PJ, Menne T, Andersen KE, Bruze M, Rastogi SC and White IR
- Year:
- 1 999
- Bibliographic source:
- Contact Dermatitis, 40(4), 196-199
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was tested by the patient in a ROAT (Repeated Open Application Test), using 1 drop (25 µl) of an ethanolic solution of the test
material, applied openly 3 times a day to a 4 cm² use test site, elbow flexure right. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-ethoxy-4-hydroxybenzaldehyde
- EC Number:
- 204-464-7
- EC Name:
- 3-ethoxy-4-hydroxybenzaldehyde
- Cas Number:
- 121-32-4
- Molecular formula:
- C9H10O3
- IUPAC Name:
- 3-ethoxy-4-hydroxybenzaldehyde
- Details on test material:
- Ethylvanillin is issued from an eau de toilette that was chemically fractionned by flash column chromatography on silica gel.
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 1
- Sex: woman
- Age: 44 years old
- Race: no data
- Demographic information: no data
- Other: no data - Clinical history:
- - History of allergy or casuistics for study subject or populations: woman with no previous problems developed an axillary rash using a perfumed deodorant. At the same time she started to use an eau de toilette of the same brand and developed a rash on the neck and on the trunk. The rash disappeared on treatment with topical corticosteroids for a few days. The patient started applying both products again and developed a generalized eczema.
- Symptoms, onset and progress of the disease: no data
- Exposure history: no data
- Aggravating factors both in home and workplace: no data
- Family history: no data
- Medical history (for respiratory hypersensitivity): no data
- Any other allergic or airway disorders: no data
- Smoking history: no data
- Other: no data - Controls:
- 10 consecutive eczema patients that were patched negative to the substance served as controls and did a 3-day ROAT with the substance in the manner similar to the patient.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Description of patch: Finn Chambers on Scanpor tape.
- Vehicle / solvent: ethanol
- Concentrations: 1%
- Volume applied: 0.15 g
- Testing/scoring schedule: 2-day occlusion and reading on Day 3.
- Removal of test substance: no data
- Other: no data
EXAMINATIONS:
- Grading/Scoring system: no data
- Statistical analysis: no data
- Other: no data
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: no symptoms appeared with Ethylvanillin.
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 1
- Number of subjects with equivocal reactions: 0
- Number of subjects with irritating reactions: 0
RESULT OF CASE REPORT: negative
OTHER RESULTS: positive reaction with Coumarin on Day 2, which is one of constituent of the perfume.
Applicant's summary and conclusion
- Conclusions:
- not sensitizing
- Executive summary:
In the study of Mutterer (1999) one woman, 44 years old, with no previous problems developed an axillary rash using a perfumed deodorant. At the same time she started to use an eau de toilette of the same brand and developed a rash on the neck and on the trunk. The rash disappeared on treatment with topical corticosteroids for a few days. The patient started applying both products again and developed a generalized eczema.
Ethylvanillin tested was issued from an eau de toilette that was chemically fractionned by flash column chromatography on silica gel. The test substance was tested at 1% in ethanol by the patient in a ROAT (Repeated Open Application Test), using 1 drop (25 µl) of the ethanolic solution applied openly 3 times a day to a 4 cm² use test site, elbow flexure right. 10 consecutive eczema patients that were patched negative to the substance served as controls and did a 3-day ROAT with the substance in the manner similar to the patient.
No sensitisation effect was reported with ethylvanillin.
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