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EC number: 204-464-7
CAS number: 121-32-4
the study of
one woman, 44 years old, with no previous problems
developed an axillary rash using a perfumed deodorant. At the same time
she started to use an eau de toilette of the same brand and developed a
rash on the neck and on the trunk. The rash disappeared on treatment
with topical corticosteroids for a few days. The patient started
applying both products again and developed a generalized eczema.
was issued from an eau de toilette that was chemically fractionned by
flash column chromatography on silica gel. The test substance was tested at
1% in ethanol by the patient in a ROAT
(Repeated Open Application Test), using 1 drop (25 µl) of the ethanolic
solution applied openly 3 times a day to a 4 cm² use test site, elbow
flexure right. 10 consecutive eczema patients that were patched negative
to the substance served as controls and did a 3-day ROAT with the
substance in the manner similar to the patient.
sensitisation effect was reported with ethylvanillin.
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