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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February-March 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Standardised method performed on all internal powders and flakes.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Particle size distribution was performed on bulk powders by laser diffraction. Sieving analysis was performed on flakes. Fine fractions (particles < 100 µm) coming from sieving analysis were characterized by laser diffraction.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Percentile:
D50
Mean:
151.4 µm
Remarks on result:
other: No source field for Standard deviation. Migrated from fields under 'Mass median diameter' as D50 percentile.
Percentile:
D10
Mean:
74.8 µm
Remarks on result:
other: No source field for Standard deviation.
Percentile:
D50
Mean:
151.4 µm
Remarks on result:
other: No source field for Standard deviation.
Percentile:
D90
Mean:
281.3 µm
Remarks on result:
other: No source field for Standard deviation.

Picture digital camera: White powder of fine crystals, with some agglomerates and lumps.

Microscope pictures:  Morphology: fine crystals from 50 to > 300 µm with various shapes, major presence of very small particles in the range 30 to 50µm.

Classes of particles<105µm : 24.2% in volume.

Conclusions:
Particle size distribution of Ethylvaniilin was characterized through laser diffraction analysis and by sieving for powder and the D50 is 151.4 µm.
Executive summary:

In a study (Rhodia 2010), particle size distribution of Ethylvanillin (purity > 99%) was characterized with pictures by digital camera and under microscopy for qualitative data. Size distribution has been investigated by standard sieving and laser granulometry methods.

The determined D50, by diffraction laser was 151.4 µm for ethylvanilline.

Description of key information

D50: 151.4µm

Additional information

Two studies were available, giving the same range of particle size.

One of them (CRTL, 2010) was chosen as key study and has reliability 1 according to Klimisch scale. The determined D50 for Ethylvanillin was 151.4 µm in this study.

The other study (Vibert, 2004) gave a particle size D50 of 200 µm, and was selected as supporting study (Klimisch scale of 2).