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EC number: 204-464-7
CAS number: 121-32-4
In a subchronic
toxicity study (Hooks, 1992), ethylvanillin was administered to CD(SD)
BR rats (males and females, 20 per sex per dose), in diet at dose levels
of 0; 500; 1000; 2000 mg/kg/day for 13 weeks. Yellow discolouration of
some or all of the fur of rats treated with 500 mg/kg/day, 1000
mg/kg/day, or 2000 mg/kg/day, were not considered to be of toxicological
For males and females,
inferior bodyweight gain was recorded in the 2000 mg/kg/day group. For
males receiving 500 or 1000 mg/kg/day, the mean bodyweight gain was
inferior to that of controls during the first 4 weeks and the cumulative
mean food intake by all the male treated groups was stastistically lower
than that of controls. The food intake by females receiving 500 or 1000
mg/kg/day was considered to be similar to that of controls throughout
the study. The decrease of bodyweight gain is observed in the fourth
first weeks, related with a decrease in food consumption. This variation
is due to the unpathability of the substance, and was not considered to
related with toxicological property of the substance.
investigations showed slightly higher than control values for
glutamic-pyruvic transaminase, alkaline phosphatase, cholesterol and
total plasma protein at the high dosage level, only occasionally
involving the intermediate dosage level. These differences from control
may be related to treatment in view of the histopathological changes in
liver. The remaining differences from the control were considered
unlikely to be of toxicological importance.
observations done on the increase of liver weight (relative), it appears
to be not correlated with hepathological changes, because these effects
were observed in the control group too, that would be due to the strain
of rat used in this study. Therefore the increase of the liver weight is
not considered as adverse effect.
The NOAEL is 1000
mg/kg bw/day based on spleen weight which is higher than control group
(relative) related with histopathological changes.
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