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EC number: 204-464-7
CAS number: 121-32-4
Two reliable studies were available. One of
them, done in accordance with the recognized guidelines, was selected as
key study, and its summary is the following:
In a 96-h acute toxicity study
(Brooke, 1984), fathead minnows (Pimephales promelas) were
exposed to ethylvanillin at nominal concentrations of 0 (control);
12.5; 25; 50; 100 & 200 mg/L under flow through conditions.
The 96-h LC50 was 87.6
mg/L. 95% C.I. (Confidence Interval): 81.4 to 94.3 mg/L (based on
Based on the criteria of the CLP
regulation, ethylvanillin is considered as harmful for Pimephales
Although GLP were not mentioned and
validity criteria not detailed, this toxicity study satisfies the
guideline requirement and is therefore considered as reliable with
Two studies were available. One of them,
done in accordance with recognized guidelines, was selected as key
study, and its summary is the following:
The 48 hours acute
toxicity of ethylvanillin to Daphnia magna was studied under static
conditions (ECT, 2017). Daphnids were exposed at nominal concentrations
of 0, 4.27, 9.39, 20.7, 45.5 and 100 mg/L (nominal concentrations) or 0,
3.96, 8.58, 17.30, 41.6 and 95.6 mg/L (measured concentrations) for 48
The 48 hours EC50
was 26.2 mg/L (measured concentrations). The
48 hours EC10 based on immobilization was 12.7 mg/L.
Based on the results
of this study, ethylvanillin is considered as harmful to Daphnia magna.
The other study (Palla, 1987) was assigned a
reliability 3 according to Klimisch scale, because the study was poorly
described and the study duration was only 24 hours. No analytical
monitoring was done.
One study was
available (ECT, 2017), with
reliability 1, and was selected as key study. Its summary was the
In a 72 hours algae study, the acute
toxicity of ethylvanillin was evaluated in the algal strain Pseudokirchneriella
supcapitata using a 72-hour static test according to current EC and
OECD guidelines, and GLP. The 72 -hour ErC50 (geometric mean) was >
100 mg/L. The 72-hour EyC50 (geometric mean) was 75.7 mg/L. The NOEC
was 21.2 mg/L. The validity criteria were fulfilled. Based on this
study, ethylvanillin is considered as not harmful to algae.
Toxicity to microorganisms:
Only one study was available (Schultz,
1997), with reliability 2, and was selected as key study. Its summary
was the following:
In a study (Schultz, 1997), the acute
toxicity of Tetrahymena pyriformis was studied under static conditions.
Microorganisms were exposed to at least 5 concentrations of
ethylvanillin. The 40-hour IC50 was 158.7 mg/L. Under these conditions,
ethylvanillin is not considered harmful to microorganisms.
Long-term toxicity to aquatic
data are available on ethylvanillin. A read-accross was done with
vanillin. One study (NIVA, 1996) with reliability 2 was available and
its summary was the following:
The effect of vanillin on the
reproduction of Daphnia magna was tested for 21 days according to the
OECD guideline 202 and GLP (NIVA, 1996). Test solutions were renewed 3
times per week. A vanillin concentration of 100 mg/L resulted in a
lethal effect starting at day 3. No lethality was observed at 56 mg/L
and lower concentrations during 21 days exposure. Sublethal effects of
vanillin included delayed occurence of the first brood, aborted broods
and reduced number of live offspring. The EC50 for effects of
reproduction (21 days) was estimated at 24 mg/L, the LOEC at 18 mg/L and
the NOEC at 10 mg/L (all nominal concentrations). Since exposure
concentrations were fluctuating, weigthed mean measured concentrations
were calculated and this resulted in an EC50 for effects on
reproduction of 16 mg/L, a NOEC of 5.9 mg/L and a LOEC of 10 mg/L.
The read-across justification is included in
section 6.1.4 of the IUCLID.
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