Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-464-7 | CAS number: 121-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Study is well described.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
- Objective of study:
- metabolism
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-ethoxy-4-hydroxybenzaldehyde
- EC Number:
- 204-464-7
- EC Name:
- 3-ethoxy-4-hydroxybenzaldehyde
- Cas Number:
- 121-32-4
- Molecular formula:
- C9H10O3
- IUPAC Name:
- 3-ethoxy-4-hydroxybenzaldehyde
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, code Crl: CD(SD)BR VAF/Plus (Marget, Kent, England)
- Age at study initiation: 7-8 weeks old (males), 9-10 weeks old (females)
- Weight at study initiation: 198-215 g
- Fasting period before study: 15 to 20 hours
- Housing: maximum 6 per cages during acclimatisation period. After dosing, rats were housed in glass metabowls equipped with urine/faeces
separators.
- Individual metabolism cages: yes/no
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days before the start of the treatment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 24°C
- Humidity (%): 40 to 60% relative humidity
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12h / 12h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on exposure:
- DIET PREPARATION
- Rate of preparation of diet (frequency): dosing solutions were freshly prepared on the day of administration.
VEHICLE
- Justification for use and choice of vehicle (if other than water): frequently used as the dose vehicle in metabolism studies of compounds with limited water solubility as it is well tolerated by rats, is water miscible, and has a high solvent capacity.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 100 and 200 mg/kg
- No. of animals per sex per dose / concentration:
- 56 animals were used (28 males and 28 females) during the study.
- Control animals:
- not specified
- Details on study design:
- - Dose selection rationale: these dose levels were selected to model those used during a 2-week dietary administration toxicokinetic study.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The test compound was therefore essentially completely absorbed
- Details on excretion:
- excretion was effectively complete at 5 days post-administration
Metabolite characterisation studies
- Details on metabolites:
- no data. However, ethylvanillin is rapidly metabolised
Any other information on results incl. tables
The test compound was therefore essentially completely absorbed and excretion was effectively complete at 5 days post-administration. Unchanged material was not detected in plasma by radio HPLC,which demonstrated that the test compound was subjected to rapid metabolism. Similary, no free ethylvanillin was detected in urine, demonstrating its complete biotransformation prior to excretion.
Clinical signs/mortality:
No adverse reactions to treatment were observed in any of the rats dosed orally with ethyl 14C-vanillin at 50, 100 or 200 mg/kg.
Applicant's summary and conclusion
- Conclusions:
- The test compound was absorbed and excretion was complete at 5 days post-administration (rat, male and female, oral).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
