Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 814-217-0 | CAS number: 353258-35-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: MAFF Japan Agricultural Chemicals Regulation Laws 2-1-3 notification 12-Nousan-8147 (2000)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31-011
Batch No.: SG0312574
Purity: 98.2%
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- (Crl: WI)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- 2.81 µm
- Geometric standard deviation (GSD):
- 2.81
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.00 ± 0.04 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No morbidity/mortality was observed in treated animals in the limit test
- Clinical signs:
- other: Animals did not demonstrate any clinical signs post exposure on day 0 thereafter up to day 14 of the observation period
- Body weight:
- Male rats exposed to 5.00 mg/L test substance demonstrated body weight gain (up to 3 to 13 g) and four female rats demonstrated body weight gain (up to 2 to 11 g) on test day 1. One female rat demonstrated body weight losses (5 g) on test day 1.Three male rats demonstrated body weight losses (up to 2 to 9 g) and two male rats demonstrated body weight gain (up to 4-6 g) on test day 3. Two female rats demonstrated body weight losses (up to 3-8 g) on test day 3 and the other female rats demonstrated body weight gain (up to 4-7 g). All the rats demonstrated body weight gains on test days 7 & 14.
- Gross pathology:
- Gross pathology examination, conducted on the day 14 for surviving animals did not reveal any macroscopic lesions
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LC50 (rat): >5.0 mg/L air
- Executive summary:
This acute inhalation toxicity study of the test substance was carried out in Wistar rats as per the OECD guideline 403, OPPTS 870.1300. Five male and five female rats were exposed nose only to 5.00 mg/L IN-QEK31 for 4 hours. The rats were observed for mortality and clinical signs of toxicity during the exposure and daily for 14 subsequent days. Body weights were measured on test days 0, 1, 3, 7 and 14.
All rats exposed to 5.00 mg/L survived the exposure and the subsequent 14-day recovery period. The rats demonstrated no clinical signs of toxicity up to day 14. Male rats exposed to 5.00 mg/L test substance demonstrated body weight gain (up to 3 to 13 g) and four female rats demonstrated body weight gain (up to 2 to 11 g) on test day 1. One female rat demonstrated body weight losses (up to 5 g) on test day 1. Three male rats demonstrated body weight losses (up to 2 to 9 g) and two male rats demonstrated body weight gain (up to 4-6 g) on test day 3. Two female rats demonstrated body weight losses (up to 3-8 g) on test day 3 and the other female rats demonstrated body weight gain (up to 4-7 g). All the rats demonstrated body weight gains on test days 7 & 14. No abnormalities were observed in the gross pathological examination of animals conducted on day 14.
Under the conditions of this study, the 4-hour inhalation median lethal concentration (LC50) for the test substance was greater than 5.00 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
