Registration Dossier
Registration Dossier
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EC number: 814-217-0 | CAS number: 353258-35-2
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- gas saturation method
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31-011
Batch No.: SG0312574
Purity: 98.2%
Results and discussion
Vapour pressureopen allclose all
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: (2.16e-10 mm Hg)
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: (2.76e-10 mm Hg)
Applicant's summary and conclusion
- Conclusions:
- Vapour pressure (20°C): 2.88 X 10e-8 Pascals (2.16 X 10e-10 mm Hg)
Vapour pressure (25°C): 3.69 X 10e-8 Pascals (2.76 X 10e-10 mm Hg) - Executive summary:
The study was conducted to determine the vapour pressure of the test substance according to the guidelines OECD 104 and OPPTS 830.7950.
The vapour pressure of the test item was determined at three gas flow rates (approximately 10, 15, and 20 mL/min) and at three temperatures (30, 40, and 50°C). The analysis of the test substance, the active ingredient, was conducted using a validated LC-MS/MS method. The mean vapour pressure values were 4.93 × 10e-8, 6.76× 10e-8 and 1.19 × 10e-7 Pa at 30, 40, and 50°C, respectively. A vapour pressure curve was plotted using inverse value of experimental temperature in K (1/T) on X-axis and vapour pressure (Log P) on Y-axis. The vapour pressure of the test item at 20 and 25°C was calculated using slope and intercept of the regression line.
Vapour pressure (20°C): 2.88 X 10e-8 Pascals (2.16 X 10e-10 mm Hg)
Vapour pressure (25°C): 3.69 X 10e-8 Pascals (2.76 X 10e-10 mm Hg)
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