8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid

Distribution modelling

Administrative data

Endpoint:

distribution modelling

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Model:

other: FOCUS surface water assessment (2001, 2015)

Media:

water - sediment

Test material

Test material information

1

Reference substance name:

8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid

Cas Number:

353258-35-2

Molecular formula:

C9H4ClF3N2O2

IUPAC Name:

8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid

Results and discussion

Percent distribution in media

Other distribution results:

Results for Cucurbits crop (IN-QEK 31):
Max. PECsw (µg/L) was 115.255 (Step 1) & 44.644 (step2)
Max. PECsed (µg/kg) was 80.600 (step 1) & 31.222 (step2)

Results for Carrot crop (IN-QEK 31):
Max. PECsw (µg/L) was 76.837 (step 1) & 29.763 (step2)
Max. PECsed (µg/kg) was 53.733 (step 1) & 20.815 (step2)

Any other information on results incl. tables

Table 1: Maximum PECs of IN-QEK31 in surface water and sediment at Steps 1, 2 and 3

FOCUS crop	Application rate (g a.s./ha)	FOCUS Step	Max. PECsw (μg/L)	Max. PECsed (μg/kg)
Vegetables, fruiting	1 × 750	Step 1	115.255	80.600
		Step 2	44.644	31.222
Vegetables, root	1 × 500	Step 1	76.837	53.733
		Step 2	29.763	20.815

Applicant's summary and conclusion

Conclusions:

Results for Cucurbits crop (IN-QEK 31):
Max. PECsw (µg/L) was 115.255 (Step 1) & 44.644 (step2)
Max. PECsed (µg/kg) was 80.600 (step 1) & 31.222 (step2)

Results for Carrot crop (IN-QEK 31):
Max. PECsw (µg/L) was 76.837 (step 1) & 29.763 (step2)
Max. PECsed (µg/kg) was 53.733 (step 1) & 20.815 (step2)

In conclusion, the FOCUS surface water assessment for DPX-Q8U80 and its metabolites indicates that the use of DPX-Q8U80 is not likely to pose a risk to surface water resources if the product is used in Europe according to the label instructions.

Executive summary:

Predicted environmental concentrations in surface water (PECsw) and sediment (PECsed) of DPX-Q8U80 and its soil and aquatic metabolites IN-QEK31, IN-REG72, IN-F4106, IN-VM862 and IN-A5760 were determined in order to support authorisation in Europe.

The active substance DPX-Q8U80 is a nematicide that can be applied to cucurbits (cucumber and courgette) pre-transplant to the field and to carrots pre-emergence. Based on the proposed GAP, the following application regimes were identified as representative for DPX-Q8U80 and considered in the modelling:

Cucurbits (cucumber, courgette) at 1 × 750 g a.s./ha, 30 days preemergence (treatment in greenhouse pre-transplant, but field assessment considered as worst case)

Carrots at 1 × 500 g a.s./ha, 40 days pre-emergence

Predicted environmental concentrations in surface water and sediment (PECsw and PECsed) of DPX-Q8U80 and its soil and aquatic metabolites IN-QEK31, IN-REG72, IN-F4106, IN-VM862 and IN-A5760 were determined following recommendations of the FOCUS surface water workgroup in a stepwise approach. The FOCUSsw crops ‘Vegetables, fruiting’ and ‘vegetables, root’ were selected for modelling, respectively.

The assessment started with the assumption of worst-case loadings at Steps 1 and 2 and was subsequently refined at Step 3. The following FOCUS surface water tools were used in simulations: Steps 1-2 in FOCUS 3.2, FOCUS SWASH 5.3, FOCUS MACRO 5.5.4, FOCUS PRZM 4.3.1 and FOCUS TOXSWA 5.5.3.

PECsw and PECsed for DPX-Q8U80 and its soil and aquatic metabolites IN-QEK31, IN-REG72, IN-F4106, IN-VM862 and IN-A5760 were calculated according to FOCUS guidelines (2001 and 2015) for application to cucurbits (cucumbers, courgettes) and carrots in Europe.

Results for Cucurbits crop (IN-QEK 31):
Max. PECsw (µg/L) was 115.255 (Step 1) & 44.644 (step2)
Max. PECsed (µg/kg) was 80.600 (step 1) & 31.222 (step2)

Results for Carrot crop (IN-QEK 31):
Max. PECsw (µg/L) was 76.837 (step 1) & 29.763 (step2)

Max. PECsed (µg/kg) was 53.733 (step 1) & 20.815 (step2)

In conclusion, the FOCUS surface water assessment for DPX-Q8U80 and its metabolites indicates that the use of DPX-Q8U80 is not likely to pose a risk to surface water resources if the product is used in Europe according to the label instructions.